具有可生物降解、细胞相容、抗菌及生物膜控制的壳聚糖磺基甜菜碱衍生物薄膜生物材料的研究  

Development of a Biodegradable,Cytocompatible,Antibacterial,and Biofilm-Controlling Chitosan Sulfobetaine Derivative Film as a Biological Material

作　　者：Maoli Yin Yingfeng Wang Xuehong Ren Tung-Shi Huang 

机构地区：[1]School of Textile and Garment,Anhui Polytechnic University,Wuhu 241000,China [2]State Key Laboratory of New Textile Materials and Advanced Processing Technologies&Key Laboratory of Textile Fiber and Products,Ministry of Education&Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials and Application,School of Textile Science and Engineering,Wuhan Textile University,Wuhan 430200,China [3]Department of Poultry Science,Auburn University,Auburn,AL 36849,USA

出　　处：《Engineering》2024年第4期95-103,共9页工程（英文）

基　　金：supported by research funding from the Starting Research Fund from the Anhui Polytechnic University(2021YQQ040);the Natural Science Foundation of Anhui Province,China(2008085QE255);the Hubei Provincial Central Leading Local Science and Technology Development Special Fund(2022BGE253).

摘　　要：The purpose of this research was to develop a chitosan sulfobetaine(CS-SNCC)film via the solutioncasting method as a biodegradable antibacterial material for biomedical applications.Chitosan and monochloro-triazine sulfobetaine were used as the raw materials for CS-SNCC preparation,and Fourier-transform infrared(FTIR),ultraviolet–visible(UV-Vis),energy-dispersive X-ray(EDX),and Xray photoelectron spectroscopy(XPS)spectra were used to characterize and analyze the structure of the synthesized CS-SNCC.Furthermore,the swelling property,thermal stability,biodegradability,cytocompatibility,and antibacterial properties of the CS-SNCC film were comprehensively investigated and compared with those of the chitosan film.The results for the film’s enzymatic biodegradation behavior show that the CS-SNCC film undergoes a weight loss of 45.54%after 21 days of incubation.In addition,the CS-SNCC film effectively resists bacterial adhesion,prevents the formation of bacteria biofilms,and exhibits high antibacterial activity,with inactivation rates of 93.43%for Escherichia coli and 91.00%for Staphylococcus aureus.Moreover,the CS-SNCC film shows good cellular activity and cytocompatibility according to the cytotoxicity results.Therefore,the prepared biodegradable,cytocompatible,antibacterial,and biofilm-controlling CS-SNCC film has potential for biomedical applications.

关 键 词：CHITOSAN SULFOBETAINE ANTIBACTERIAL Biofilm-controlling Film 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.2[医药卫生—基础医学]