西维来司他钠联合乌司他丁对ARDS患者炎性反应、血气水平的影响  

Effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome

作　　者：王瑾[1] 周冠华[1] 王助衡[1] WANG Jin;ZHOU Guanhua;WANG Zhuheng(Beijing Daxing District People’s Hospital,Beijing 102600,China)

机构地区：[1]北京市大兴区人民医院,102600

出　　处：《河北医药》2024年第12期1810-1813,共4页Hebei Medical Journal

摘　　要：目的比较西维来司他钠联合乌司他丁对急性呼吸窘迫综合征(ARDS)患者的影响。方法选取2021年5月至2023年5月诊治的202例ARDS患者进行研究,按抛硬币法将所有患者分为A组(n=101例,乌司他丁治疗)和B组(n=101例,西维来司他钠联合乌司他丁治疗)。记录2组患者生命体征(血压、心率、体温、呼吸)、炎性反应[降钙素原(PCT)、内毒素脂多糖(LPS)、溶酶体酶(LE)]、血气指标[氧合指数(PaO_(2)/FiO_(2))、血乳酸(Lac)、活性碳酸酐酶(CA)]、肺功能[肺动态顺应性(Cdyn)、预测性呼气末正压(PEEP)、气道阻力(Raw)]水平及不良反应变化。结果治疗后,2组患者心率、体温、呼吸水平显著降低(P<0.05),而血压水平显著增加(P<0.05),2组患者生命体征指标无显著变化(P>0.05);2组患者PCT、LPS、LE、Lac、PEEP、Raw水平显著降低(P<0.05),且B组低于A组(P<0.05);2组患者PaO_(2)/FiO_(2)、CA、Cdyn水平显著增加(P<0.05),且B组高于A组(P<0.05);2组不良反应无显著差异(P>0.05)。结论西维来司他钠联合乌司他丁治疗ARDS效果显著,可有效改善患者生命体征指标、炎性水平、血气指标和肺功能。Objective To detect the effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome(ARDS).Methods A total of 202 ARDS patients admitted in our hospital from May 2021 to March 2023 were enrolled.According to the coin toss methods,patients were assigned into group A(n=101,treatment of ulinastatin)and group B(n=101,treatment of sivelestat sodium combined with ulinastatin).Vital signs(blood pressure,heart rate,body temperature,respiration),inflammatory response(procalcitonin[PCT],lipopolysaccharide[LPS],lysosomal enzyme[LE]),blood gas(oxygenation index[PaO_(2)/FiO_(2)],blood lactic acid[Lac],active carbonic anhydrase[CA]),pulmonary function(dynamic lung compliance[Cdyn],positive end expiration pressure[PEEP],airway resistance[Raw])and adverse events were compared between groups.Results After treatment,significantly decreased heart rate,temperature and respiratory rate,and significantly increased blood pressure were detected in both groups(P<0.05).No significant differences in the vital signs after treatment were detected between groups(P>0.05).PCT,LPS,LE,Lac,PEEP and Raw were significantly decreased in both groups after treatment,which were significantly lower in group B than those of Group A(P<0.05).PaO_(2)/FiO_(2),CA and Cdyn were significantly increased in both groups after treatment,which were significantly higher in group B than those of Group A(P<0.05).No significant difference in the incidence of adverse events was detected between groups(P>0.05).Conclusion Sivelestat sodium combined with ulinastatin offers an excellent therapeutic efficacy on ARDS,which greatly improve vital signs,inflammatory response,blood gas and pulmonary function.

关 键 词：西维来司他钠 乌司他丁 急性呼吸窘迫综合征 血气指标 

分 类 号：R563.9[医药卫生—呼吸系统]