增强型体外反搏联合硝苯地平控释片治疗老年单纯收缩期高血压的效果  

Effect of enhanced external counterpulsation combined with nifedipine controlled-release tablets in the treatment of isolated systolic hypertension in the elderly

作　　者：刘爽 卢江曼 张刚 杨云 LIU Shuang;LU Jiangman;ZHANG Gang(Department of Cardiology,the Eighth People’s Hospital of Hebei Province,Hebei,Shijiazhuang 050000,China)

机构地区：[1]河北省第八人民医院心内科,石家庄市050000

出　　处：《河北医药》2024年第12期1834-1837,共4页Hebei Medical Journal

基　　金：河北省医学科学研究项目(编号:20210646)。

摘　　要：目的 分析探讨增强型体外反搏联合硝苯地平控释片治疗老年单纯收缩期高血压的效果。方法 选取2021年3月至2022年12月收治的80例老年单纯收缩期高血压老年患者为研究对象,随机分为对照组和观察组,每组40例。对照组以硝苯地平控释片治疗,观察组增加增强型体外反搏治疗。疗程结束后评估患者的临床疗效、血压波动性、肾功能指标、生活质量评分、治疗安全性。结果 观察组总有效率为92.50%,高于对照组的75.00%(P<0.05)。治疗后,观察组患者24 h平均收缩压(24 h mSBP)、24 h动态血压标准差(SD)、24 h动态血压变异系数(CV)均低于对照组(P<0.05)。治疗后,观察组尿微量白蛋白(MAU)、尿肌酐清除率(UCr)、尿微量白蛋白/肌酐比值(ACR)均低于对照组(P<0.05)。治疗后,观察组生活质量综合评定问卷(GQOLI-74)各项评分高于对照组(P<0.05)。2组不良反应发生率为15.00%(6/40)、10.00%(4/40),差异无统计学意义(P>0.05)。结论 增强型体外反搏联合硝苯地平控释片治疗老年单纯收缩期高血压的效果良好,可降低患者血压波动性,改善患者肾功能指标,提高患者的日常生活质量水平,有较好的安全性,可在临床推广应用。Objective To analyze the effect of enhanced external counterpulsation(EECP)combined with nifedipine controlled-release tablets in the treatment of isolated systolic hypertension in the elderly.Methods A total of 80 elderly patients with isolated systolic hypertension admitted from March 2021 to December 2022 were enrolled.They were randomly assigned into the control group and observation group,with 40 cases per group.Patients in both groups were treated with nifedipine controlled-release tablets,and those in the observation group were additionally given EECP.The clinical efficacy,blood pressure volatility,renal function indicators,and treatment safety were evaluated after treatment.Results The total effective rate was significantly higher in the observation group than that of control group(92.50%[37/40]vs 75.00%[30/40],P<0.05).After treatment,the 24-hour mean systolic blood pressure(24 h mSBP),24-h ambulatory blood pressure standard deviation(SD),and 24-h ambulatory blood pressure coefficient of variation(CV)were significantly lower in the observation group than those of the control group(P<0.05).After treatment,urinary microalbumin(MAU),urinary creatinine clearance(UCr),and urinary albumin/creatinine ratio(ACR)were significantly lower in the observation group than those of the control group(P<0.05).No significant difference was detected in the incidence of adverse events(15.00%[6/40]vs 10.00%[4/40],P>0.05).Conclusion EECP combined with nifedipine controlled-release tablets has good results in treating isolated systolic hypertension in the elderly,which can reduce the fluctuation of blood pressure and improve the renal function with a good safety.

关 键 词：收缩期高血压 硝苯地平控释片 增强型体外反搏 血压波动 肾功能 生活质量 

分 类 号：R544.1[医药卫生—心血管疾病]