调整空腹C肽、HbA1c及果糖胺含量对2型糖尿病患者慢性并发症发生率的影响  

Effect of adjusting fasting C-peptide, HbA1c and fructosamine on the incidence of chronic complications in patients with type 2 diabetes mellitus

作　　者：周祥兵 汤彩 高文龙 ZHOU Xiangbing;TANG Cai;GAO Wenlong(Department of Endocrinology,the People’s Hospital of Susong,Anhui,Anqing 246500,China)

机构地区：[1]安徽省宿松县人民医院内分泌科,246500

出　　处：《河北医药》2024年第12期1838-1841,共4页Hebei Medical Journal

摘　　要：目的 探究以调整空腹C肽、糖化血红蛋白(HbA1c)及果糖胺含量为视角的2型糖尿病(T2DM)患者减少慢性并发症对策。方法 选择2019年3月至2020年4月收治的T2DM患者116例作为研究对象,采用随机数字表法分为对照组及观察组,均为58例。对照组给予标准糖尿病治疗和管理,观察组在对照组基础上给予调整空腹C肽、HbA1c及果糖胺含量的干预对策,2组治疗前、治疗6个月的血糖水平、胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、空腹C肽及果糖胺含量,统计3年内慢性并发症发生情况。结果 治疗6个月,观察组FBG、2hPBG、HbA1c水平水平均低于对照组(P<0.05)。治疗6个月,观察组的BMI、HOMA-IR低于对照组(P<0.05),腰围、臀围小于对照组(P<0.05)。治疗6个月,观察组空腹C肽及果糖胺含量水平均低于对照组(P<0.05)。观察组3年内慢性并发症发生率低于对照组(P<0.05)。结论 以调整空腹C肽、HbA1c及果糖胺含量为视角的干预对策能够有效减少T2DM患者慢性并发症,改善血糖水平,改善体态,值得推广。Objective To investigate the interventions to reduce chronic complications in patients with type 2 diabetes mellitus(T2DM)through adjusting fasting C-peptide,glycosylated hemoglobin(HbA1c)and fructosamine content.Methods One hundred and sixteen patients with T2DM admitted to our hospital during March 2019 to April 2020 were enrolled.They were randomly assigned into the control group and observation group using a random number table method,with 58 cases per group.All patients were intervened by the standard diabetes treatment and management,and those in the observation group were additionally given interventions based on the adjustments of fasting C-peptide,HbA1c and fructosamine content.The fasting blood glucose(FBG),homeostatic model assessment for insulin resistance(HOMA-IR),body mass index(BMI),fasting C-peptide and fructosamine before and at 6 months after treatment were measured.Chronic complications within 3 years were recorded.Results At 6 months of treatment,T2DM patients in the observation group had significantly lower FBG,2-h postprandial blood glucose(2hPBG)and hemoglobin A1C(HbA1c)than those of the control group(P<0.05).At 6 months of treatment,BMI,HOMA-IR and waist and hip circumferences in the observation group were significantly lower than those of the control group(all P<0.05).Fasting C-peptide and fructosamine at 6 months of treatment were significantly lower in the observation group than those of the control group(P<0.05).The incidence of chronic complications within 3 years in the observation group was significantly lower than that of the control group(P<0.05).Conclusion The interventions based on adjusting fasting C peptide,HbA1c and fructosamine content can effectively reduce chronic complications,lower blood glucose levels and improve body posture in T2DM patients,which is worth promoting.

关 键 词：空腹C肽 HBA1C 果糖胺含量 2型糖尿病 慢性并发症 

分 类 号：R587.1[医药卫生—内分泌]