苏黄止咳胶囊联合盐酸西替利嗪片治疗感冒后咳嗽的效果  

Efficacy and mechanism of Suhuang Zhike Capsules combined with cetirizine hydrochloride tablets on postinfectious cough

作　　者：姜锋[1] 秦良楠 杨林瀛[1] 庞桂芬[1] 米术斌[2] 张艳敏[1] 李海月 韩梅[1] JIANG Feng;QIN Liangnan;YANG Linying(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Chengde Medical University,Hebei,Chengde 067000,China)

机构地区：[1]承德医学院附属医院呼吸与危重症医学科,河北省承德市067000 [2]承德医学院统计学教研室,河北省承德市067000

出　　处：《河北医药》2024年第12期1856-1858,共3页Hebei Medical Journal

基　　金：承德市科学技术研究与发展计划项目(编号:202109A187)。

摘　　要：目的 探讨苏黄止咳胶囊联合盐酸西替利嗪片治疗感冒后咳嗽的效果。方法 选取2020年10月至2022年2月感冒后咳嗽患者90例,随机数字法分为3组,A组接受苏黄止咳胶囊治疗30例,B组接受盐酸西替利嗪片治疗30例,C组为上述药物联合应用治疗30例,对3组所得不同治疗结局进行分析。结果 3组治疗前咳嗽症状总评分、咳嗽视觉模拟评分、FeNO水平对比,差异无统计学意义(P>0.05);C组治疗后咳嗽总评分、咳嗽视觉模拟评分,优于A、B组(P<0.05);A、B组治疗后咳嗽总评分、咳嗽视觉模拟评分对比,差异无统计学意义(P>0.05);C组治疗后FeNO水平优于A、B组(P<0.05);A、B组治疗后FeNO水平对比,差异无统计学意义(P>0.05);C组治疗有效率,高于A、B组(P<0.05);A、B组治疗有效率差异无统计学意义(P>0.05)。A、B、C组治疗前EV1/FVC较治疗后显著偏低(P<0.05),组间EV1/FVC差异无统计学意义(P>0.05)。结论 感冒后咳嗽患者,使用苏黄止咳胶囊与盐酸西替利嗪片治疗,可有效改善患者临床咳嗽症状,提高治疗有效率,临床价值较为明显。Objective To explore the efficacy and mechanism of Suhuang Zhike capsules combined with cetirizine hydrochloride tablets on postinfectious cough.Methods A total of 90 patients with postinfectious cough from October 2020 to February 2022 were enrolled.Patients were randomly assigned into group A(Suhuang Zhike Capsules,n=30),group B(cetirizine hydrochloride tablets,n=30)and group C(Suhuang Zhike Capsules plus cetirizine hydrochloride tablets,n=30).The treatment outcomes were analyzed among three groups.Results There were no significant differences in the total score of cough symptom,Visual Analog Scale(VAS)score for cough symptom,and fractional exhaled nitric oxide(FeNO)level among three groups before treatment(P>0.05).The total score of cough symptom and VAS score of cough in group C were significantly better than those of group A and group B(P<0.05).There were no significant differences in the total score of cough symptom and VAS score for cough symptom between group A and group B after treatment(P>0.05).FeNO level after treatment in group C was significantly better than that of group A and group B(P<0.05),which was comparable between group A and group B(P>0.05).The effective rate in group C was significantly higher than that in group A and B(P<0.05),which was comparable between group A and group B(P>0.05).In groups A,B and C,forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC)was significantly lower after treatment than that before treatment(P<0.05),which was comparable among the three groups(P>0.05).Conclusion For patients with postinfectious cough,Suhuang Zhike Capsules combined with cetirizine hydrochloride tablets can effectively improve patients’cough symptoms,and enhance the effective rate of treatment,with a definite clinical value.

关 键 词：感冒后咳嗽 苏黄止咳胶囊 盐酸西替利嗪片 视觉模拟评分 

分 类 号：R511.6[医药卫生—内科学]