头孢曲松钠联合醒脑静治疗小儿化脓性脑膜炎的有效性和安全性  

Effectiveness and safety of ceftriaxone sodium combined with wake-up call in the treatment of children with purulent meningitis

作　　者：梁雪敏 杨青晓 赵丹丹 魏振宇 焦艳顺 LIANG Xuemin;YANG Qingxiao;ZHAO Dandan(Handan Second Hospital,Hebei,Handan 056000,China)

机构地区：[1]河北省邯郸市第二医院,056000 [2]河北省邢台市任泽区人民医院 [3]河北省衡水市第六人民医院

出　　处：《河北医药》2024年第13期1955-1959,共5页Hebei Medical Journal

摘　　要：目的 探讨头孢曲松钠联合醒脑静治疗小儿化脓性脑膜炎的有效性和安全性。方法 选取2020年2月至2023年2月收治的小儿化脓性脑膜炎100例,随机数字表法分为对照组和联合组,每组50例。对照组予以头孢曲松钠治疗,联合组予以头孢曲松钠联合醒脑静治疗。对比2组临床疗效、症状缓解时间,治疗前后炎性因子[C反应蛋白(CRP)、白介素-6(IL-6)、白介素-4(IL-4)、降钙素原(PCT)]、血清相关指标[神经元特异性烯醇化酶(NSE)、基质金属蛋白酶-9(MMP-9)、可溶性B7同源体3(sB7-H3)、一氧化氮(NO)、白细胞计数、糖定量、蛋白定量水平、氯化物]以及用药安全性。结果 联合组治疗总有效率为94.00%高于对照组的80.00%(P<0.05)。联合组患儿体温恢复正常、脑脊液恢复正常、白细胞恢复以及住院时间均短于对照组(P<0.05)。治疗后,2组血清CRP、IL-6、IL-4、PCT、NSE、MMP-9、sB7-H3、NO、白细胞计数、蛋白定量水平均低于治疗前,且联合组低于对照组(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 小儿化脓性脑膜炎采用头孢曲松钠联合醒脑静治疗可有效缩短症状缓解时间,减轻炎性反应,减少神经系统损害,减轻脑脊液压力,治疗安全有效。Objective To investigate the effectiveness and safety of ceftriaxone sodium combined with wake-up call in the treatment of children with purulent meningitis(PM).Methods A total of 100 children with PM treated from February 2020 to February 2023 were randomly assigned into control group(n=50)and combination group(n=50).All patients were managed by ceftriaxone sodium,and those in combination group were additionally treated with wake-up call.The aim was to compare symptom relief time,inflammatory factors(C-reactive protein[CRP],interleukin-6[IL-6],interleukin-4[IL-4],procalcitonin[PCT]),serum related indexes(neuron-specific enolase[NSE],matrix metalloproteinase-9[MMP-9],soluble B cell antigen 7 homolog 3[sB7-H3],nitric oxide[NO],white blood cell count,glucose quantitative,protein quantitative level,chloride).The curative effect and medication safety were assessed.Results The overall effective rate in the combination group was significantly higher than that in the control group(94.00%vs 80.00%,P<0.05).The recovery time of body temperature,cerebrospinal fluid,leucocyte,and the hospitalization time were significantly shorter in the combination group than in the control group(P<0.05).After treatment,CRP,IL-6,IL-4,PCT,NSE,MMP-9,sB7-H3,NO,white blood cell count,protein quantitative level in the both groups were significantly decreased(P<0.05),which decreased notably in the combination group compared with the control group(P<0.05).The total incidence of adverse reactions between the two groups was comparable(P>0.05).Conclusion For children with PM,ceftriaxone sodium combined with wake-up call can effectively shorten the symptom relief time,reduce inflammatory response,nerve system damages and cerebrospinal fluid pressure,and it is safe and effective.

关 键 词：化脓性脑膜炎 头孢曲松钠 醒脑静 症状缓解 有效性 安全性 

分 类 号：R512.2[医药卫生—内科学]