α1-微球蛋白、C反应蛋白联合尿白蛋白/尿肌酐在糖尿病早期肾病中的诊断价值  

Diagnostic Value of α1-microglobulin, C-reactive Protein Combined with Urine Albumin-to-creatinine Ratio in Early Diabetic Nephropathy

作　　者：李兴华 张明霞 丁艳红 LI Xinghua;ZHANG Mingxia;DING Yanhong(Department of Laboratory,Tai'an 88 Hospital,Tai'an,Shandong Province,271000 China)

机构地区：[1]泰安八十八医院检验科,山东泰安271000

出　　处：《系统医学》2024年第10期38-41,共4页Systems Medicine

摘　　要：目的探究α1-微球蛋白(Alpha-1 Microglobulin,α1-MG)、C反应蛋白(C-reactive Protein,CRP)联合尿白蛋白/尿肌酐(Urine Albumin-To-Creatinine Ratio,UACR)在糖尿病早期肾病中的诊断价值。方法选取2022年1月—2023年11月泰安八十八医院收治的200例单纯糖尿病患者作为观察A组、同时选取200例糖尿病早期肾病患者作为观察B组,并选取120名健康体检人员作为对照组。所有研究对象均采取α1-MG、CRP、UACR指标检测,并分析α1-MG、CRP联合UACR在糖尿病早期肾病中的诊断价值。结果观察B组α1-MG(38.92±8.02)mg/L、CRP(4.06±1.13)mg/L及UACR(38.14±7.52)mg/g均高于对照组及观察A组,且观察A组各水平高于对照组,差异有统计学意义(F=362.467,572.042,729.165,P均<0.05)。α1-MG、CRP联合UACR诊断糖尿病早期肾病的准确度(86.54%)、特异度(88.75%)、灵敏度(83.00%)均高于各项指标单一检测。结论对于糖尿病早期肾病患者来说,应当进行及早诊断和治疗,而α1-MG、CRP及UACR在糖尿病早期肾病中具有一定的指示作用。Objective To explore the diagnostic value ofα1-microglobulin(α1-MG),C-reactive protein(CRP)com⁃bined with urine albumin-to-creatinine ratio(UACR)in early diabetic nephropathy.Methods Two hundred patients with simple diabetes admitted to Tai'an 88 Hospital from January 2022 to November 2023 were selected as observa⁃tion group A,two hundred patients with early diabetic nephropathy were selected as observation group B,and one hun⁃dred and twenty healthy physical examination personnel were selected as control group.All subjects were measured byα1-MG,CRP,and UACR.And the diagnostic value ofα1-MG,CRP and UACR in early diabetic nephropathy was analyzed.Resultsα1-MG(38.92±8.02)mg/L,CRP(4.06±1.13)mg/L and UACR(38.14±7.52)mg/g in observation group B were higher than those in control group and observation group A,and observation group A was higher than control group,and differences were statistically significant(F=362.467,572.042,729.165,all P<0.05).The accuracy(86.54%),specificity(88.75%)and sensitivity(83.00%)ofα1-MG and CRP combined with UACR in the diagnosis of early diabetic nephropathy were higher than that of single detection.Conclusion For patients with early diabetic ne⁃phropathy,early diagnosis and treatment should be carried out,andα1-MG,CRP and UACR have certain indicative roles in early diabetic nephropathy.

关 键 词：Α1-微球蛋白 C反应蛋白 尿白蛋白/尿肌酐 糖尿病早期肾病 诊断价值 

分 类 号：R4[医药卫生—临床医学]