右美托咪定联合丙泊酚麻醉在老年无痛胃肠镜检查患者中的应用效果  

Effectiveness of Dexmedetomidine Combined with Propofol Anesthesia Regimen in Elderly Patients Undergoing Painless Gastroenteroscopy

作　　者：陈攀荣 刘义鑫[1] 董发宇 CHEN Panrong;LIU Yixin;DONG Fayu(Department of Anesthesiology,Panzhihua Central Hospital,Panzhihua,Sichuan Province,617000 China)

机构地区：[1]攀枝花市中心医院麻醉科,四川攀枝花617000

出　　处：《系统医学》2024年第10期53-56,63,共5页Systems Medicine

摘　　要：目的分析右美托咪定+丙泊酚对老年无痛胃肠镜检查患者的影响。方法选取2021年8月—2023年8月于攀枝花市中心医院接受无痛胃肠镜检查的94例老年患者为研究对象,按随机数表法分为两组,各47例。对照组予以丙泊酚,观察组加用右美托咪定。对比两组麻醉效果、苏醒情况、血流动力学、应激反应、不良反应。结果观察组Ramsay镇静评分为(4.35±0.67)分,高于对照组的(3.94±0.51)分,差异有统计学意义(t=3.338,P<0.05)。观察组苏醒情况优于对照组,差异有统计学意义(P<0.05)。观察组检查开始时(T1)、检查结束时(T2)的平均动脉压、心率、血氧饱和度高于对照组,观察组T2的去甲肾上腺素、皮质醇、肾上腺素低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论右美托咪定结合丙泊酚能够保障老年无痛胃肠镜检查患者血流动力学稳定,减轻应激反应,促进苏醒,且无严重不良反应。Objective To analyze the effects of dexmedetomidine+propofol on elderly painless gastroenteroscopy pa-tients.Methods 94 elderly patients received painless gastroenteroscopy in Panzhihua Central Hospital from August 2021 to August 2023 were selected as the study objects and were divided into two groups with 47 cases in each group according to the random number table method.Propofol was given to the control group and dexmedetomidine were added to the observation group.The anesthetic effect,awakening,hemodynamics,stress reaction,and adverse reaction were compared between the two groups.Results The Ramsay sedation score of the observation group was(4.35±0.67)points,which was higher than(3.94±0.51)points of the control group,the difference was statistically significant(t=3.338,P<0.05).The awakening situation of the observation group were better than those of the control group,the dif-ferences was statistically significant(P<0.05).The mean arterial pressure,heart rate,and oxygen saturation at the be-ginning of the examination(T1)and the end of the examination(T2)of the observation group were higher than those of the control group,and norepinephrine,cortisol and epinephrine in the observation group at T2 were lower than those in the control group,the differences were statistically significant(all P<0.05).There was no statistically significant dif-ference in the adverse effects between the two groups(P>0.05).Conclusion Dexmedetomidine combined with propofol was able to guarantee hemodynamic stability,reduce stress reaction,and promote awakening in elderly painless gastro-enteroscopy patients without serious adverse reactions.

关 键 词：无痛胃肠镜 右美托咪定 丙泊酚 不良反应 应激反应 肾上腺素 

分 类 号：R614[医药卫生—麻醉学]