血浆NT-proBNP与急性非ST段抬高心肌梗死患者冠脉病变严重程度的相关性研究  

Correlation between Plasma NT-proBNP and Coronary Artery Lesion Severity in Patients with Acute Non-ST Elevation Myocardial Infarction

作　　者：朱张国 桂家晶 杨娟 李茂 ZHU Zhangguo;GUI Jiajing;YANG Juan;LI Mao(Department of Cardiology,Anshun Pingba District People's Hospital,Anshun,Guizhou Province,561000 China)

机构地区：[1]安顺市平坝区人民医院心内科,贵州安顺561000

出　　处：《系统医学》2024年第10期96-99,共4页Systems Medicine

摘　　要：目的探讨急性非ST段抬高心肌梗死(Non-ST Elevation Myocardial Infarction,NSTEMI)患者血浆N端B型脑钠肽前体(N-terminal pro-B-type Natriuretic Peptide,NT-proBNP)与冠脉病变严重程度的相关性。方法选取2020年1月—2023年10月安顺市平坝区人民医院心内科收治的54例行介入治疗的NSTEMI患者作为观察组,选取同期行冠脉造影检查结果正常的50例患者作为对照组,对两组患者的NT-proBNP进行检测比较,根据病变严重程度将观察组患者分为轻度病变组(15例)、中度病变组(28例)和重度病变组(11例),对3组患者的NT-proBNP进行比较,分析NT-proBNP与冠脉病变严重程度的相关性。结果观察组NT-proBNP水平(615.43±111.32)pg/mL明显高于对照组(76.43±16.43)pg/mL,差异有统计学意义(t=33.885,P<0.05)。轻度病变组的NT-proBNP水平明显低于中度病变组和重度病变组,差异有统计学意义(P均<0.05),中度病变组的NT-proBNP明显低于重度病变组,差异有统计学意义(P<0.05)。相关性分析结果显示,NSTEMI患者NT-proBNP水平与冠脉病变呈正相关(r=0.683,P<0.001)。结论NSTEMI患者NT-proBNP水平与冠脉病变呈正相关,患者NT-proBNP水平可为患者的疾病严重程度和临床治疗提供指导。Objective To investigate the correlation between plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP)and the severity of coronary artery lesions in patients with acute non-ST elevation myocardial infarction(NSTEMI).Methods A total of 54 NSTEMI patients undergoing interventional therapy admitted to the Department of Cardiology of Anshun Pingba District People's Hospital from January 2020 to October 2023 were selected as the ob-servation group,and 50 patients with normal coronary angiography results during the same period were selected as the control group.The detection and comparison of NT-proBNP in the two groups were conducted.According to the sever-ity of the lesions,patients in the observation group were divided into a mild lesion group(15 cases),a moderate lesion group(28 cases)and a severe lesion group(11 cases).The NT-proBNP levels in the 3 groups were compared to ana-lyze the correlation between NT-proBNP and the severity of coronary lesions.Results The level of NT-proBNP in ob-servation group[(615.43±111.32)pg/mL]was significantly higher than that in control group[(76.43±16.43)pg/mL],the difference was statistically significant(t=33.885,P<0.05).The level of NT-proBNP in the mild lesion group was significantly lower than that in the moderate lesion group and the severe lesion group,the differences were statistically significant(both P<0.05),and the level of NT-proBNP in the moderate lesion group was significantly lower than that in the severe lesion group,the difference was statistically significant(P<0.05).Correlation analysis showed that NT-proBNP levels were positively correlated with coronary lesions in NSTEMI patients(r=0.683,P<0.001).Conclusion NT-proBNP levels in NSTEMI patients were positively correlated with coronary artery lesions,and NT-proBNP levels in patients can provide guidance for disease severity and clinical treatment.

关 键 词：急性心肌梗死 冠脉病变程度 N末端B型脑钠肽前体 相关性 

分 类 号：R54[医药卫生—心血管疾病]