空腹血糖和糖化血红蛋白联合检测在妊娠期糖尿病筛查中的应用价值  

Application Value of Combined Detection of Fasting Blood Glucose and Glycated Hemoglobin in Screening of Gestational Diabetes Mellitus

作　　者：赵丽娜 孙鑫 魏红[1] ZHAO Li'na;SUN Xin;WEI Hong(Department of Clinical Laboratory,Weifang Hospital of Traditional Chinese Medicine,Weifang,Shandong Province,261041 China)

机构地区：[1]潍坊市中医院检验科,山东潍坊261041

出　　处：《系统医学》2024年第10期162-164,168,共4页Systems Medicine

摘　　要：目的探讨空腹血糖(Fasting Plasma Glucose,FPG)和糖化血红蛋白(Glycosylated Hemoglobin A1c,HbA1c)联合检测在妊娠期糖尿病筛查中的应用价值。方法回顾性选取2023年2—9月潍坊市中医院进行产检孕妇的临床资料,选取妊娠期糖尿病孕妇共60例为观察组,选取同期来本院做产前检查的正常妊娠妇女60名为对照组。所有孕妇均进行FPG、HbA1c等指标检测,根据口服糖耐量试验(Oral Glucose Tolerance Test,OGTT)结果诊断妊娠期糖尿病。绘制受试者操作特征(Receiver Operating Characteristic,ROC)曲线对比HbA1c检测、FPG检测、二者联合检测对妊娠期糖尿病的预测价值。结果与对照组相比,观察组HbA1c、FPG较高,差异有统计学意义(P均<0.05),单纯HbA1c和FPG检测方法的预测价值较低,而两者联合检测预测价值较高,ROC曲线下面积分别是0.805、0.743、0.842。结论FPG和HbA1c联合检测在妊娠期糖尿病早期筛查中具有较高的应用价值。与单一的FPG或HbA1c检测相比,联合检测能够更准确地评估妊娠期糖尿病的风险,显著提高筛查的准确性。Objective To investigate the application value of fasting plasma glucose(FPG)and glycosylated hemoglo⁃bin A1c(HbA1c)combined detection in gestational diabetes screening.Methods The clinical data of pregnant women who received prenatal examination in Weifang Hospital of Traditional Chinese Medicine from February to September 2023 were retrospective selected.A total of 60 pregnant women with gestational diabetes were selected as the observa⁃tion group,and 60 normal pregnant women who came to the hospital for prenatal examination at the same period were selected as the control group.All pregnant women were tested for FPG,HbA1c and other indicators.Gestational diabe⁃tes mellitus was diagnosed based on the results of oral glucose tolerance test(OGTT).the receiver operating character⁃istic(ROC)curve was drawn to compare the predictive value of HbA1c detection,FPG detection and combined detec⁃tion for gestational diabetes mellitus.Results Compared with the control group,the HbA1c and FPG in the observa⁃tion group were higher,and the differences were statistically significant(both P<0.05).The prediction value of pure HbA1c and FPG detection was low,while the combined detection of HbA1c and FPG detection was high,and the area under ROC curve were 0.805,0.743 and 0.842,respectively.Conclusion The combined detection of FPG and HbA1c has high application value in the early screening of gestational diabetes mellitus.Compared with the FPG or HbA1c test alone,the combined test is able to more accurately assess the risk of gestational diabetes,significantly improving the accuracy of screening.

关 键 词：空腹血糖 糖化血红蛋白 妊娠期糖尿病 

分 类 号：R4[医药卫生—临床医学]