血清INHB、IGF-1、VEGF、E_(2)在多囊卵巢综合征患者中的表达及临床意义  

Expression and Clinical Significance of Serum INHB,IGF-1,VEGF and E2 in Patients with Polycystic Ovary Syndrome

作　　者：刘泽瑶 LIU Zeyao(Department of Clinical Laboratory,Hulun Buir Maternal and Child Health Hospital,Hulun Buir,Inner Mongolia Autonomous Region,811299 China)

机构地区：[1]呼伦贝尔市妇幼保健院检验科,内蒙古呼伦贝尔811299

出　　处：《系统医学》2024年第10期176-179,共4页Systems Medicine

摘　　要：目的探究多囊卵巢综合征患者血清抑制素B(Serum Inhibin B,INHB)、血管内皮生长因子(Vascular Endothelial Growth Factors,VEGF)、类胰岛素样生长因子1(Insulin-like Growth Factor-1,IGF-1)、雌二醇(Es⁃tradiol,E2)的表达及临床意义。方法选取2021年5月—2022年7月呼伦贝尔市妇幼保健院收治的40例多囊卵巢综合征患者为研究组,选取40名同期健康体检者为对照组,对比血清指标检测水平、不同严重程度多囊卵巢综合征血清指标的表达量差异、研究胰岛素抵抗指数与血清INHB、IGF-1、VEGF、E2的相关性。结果研究组的INHB(185.96±42.05)pg/mL、VEGF(913.46±94.36)ng/L、IGF-1(164.23±18.54)ng/mL、E2(198.28±34.62)pmol/L水平均高于对照组,差异有统计学意义(t=10.226、15.103、12.710、4.657,P均<0.05)。研究组重度患者的血清INHB、IGF-1、VEGF、E2水平均高于轻度、中度患者,差异有统计学意义(P均<0.05)。血清指标INHB、IGF-1、VEGF、E2与多囊卵巢综合征患者疾病呈正相关(r=0.356、0.419、0.486、0.512,P均<0.05)。结论在多囊卵巢综合征中INHB、VEGF、IGF-1、E2均呈现高表达,能够为临床诊治多囊卵巢综合征提供客观依据。Objective To explore the expression and clinical significance of serum inhibin B(INHB),vascular endo-thelial growth factors(VEGF),insulin-like growth factor-1(IGF-1)and estradiol(E2)in patients with polycystic ovary syndrome(PCOS).Methods 40 patients with polycystic ovary syndrome admitted to Hulunbeier Maternal and Child Healthcare Hospital from May 2021 to July 2022 were selected as the study group,and 40 people who had a health check-up during the same period were selected as the control group.The serum indicators,detection level,expression difference of serum indicators in different severity of PCOS were compared,correlation between insulin resistance in-dex and serum INHB,IGF-1,VEGF and E2 were studied.Results The levels of INHB(185.96±42.05)pg/mL,VEGF(913.46±94.36)ng/L,IGF-1(164.23±18.54)ng/mL,E_(2)(198.28±34.62)pmol/L in the study group were higher than those in the control group,the difference was statistically significant(t=10.226,15.103,12.710,4.657,all P<0.05).The levels of serum INHB,IGF-1,VEGF and E_(2) in severe patients were higher than those in mild and moderate pa-tients,and the differences were statistically significant(all P<0.05).Serum indexes INHB,IGF-1,VEGF and E_(2) were positively correlated with the disease of PCOS patients(r=0.356,0.419,0.486,0.512,all P<0.05).Conclusion Serum inhibin B,vascular endothelial growth factor,insulin-like growth factor-1 and estradiol are all highly expressed in PCOS,which can provide an objective basis for clinical diagnosis and treatment of PCOS.

关 键 词：血清抑制素B 多囊卵巢综合征 血管内皮生长因子 

分 类 号：R711.75[医药卫生—妇产科学]