使用盐酸羟考酮缓释片治疗晚期癌痛的药学作用探讨  

Pharmacologic Effect of Oxycodone Hydrochloride Sustained-release Tablets in the Treatment of Advanced Cancer Pain

作　　者：黄晶晶[1] 沈杉松 张扬 HUANG Jingjing;SHEN Shansong;ZHANG Yang(Department of Pharmacy,Rugao Boai Hospital(Rugao Branch of the Affiliated Hospital of Nantong University),Rugao,Jiangsu Province,226500 China)

机构地区：[1]如皋博爱医院(南通大学附属医院如皋分院)药剂科,江苏如皋226500

出　　处：《系统医学》2024年第10期183-186,共4页Systems Medicine

摘　　要：目的探讨使用盐酸羟考酮缓释片治疗晚期癌痛药学作用。方法选取2020年8月—2023年7月如皋博爱医院收治的156例晚期癌痛患者作为研究对象,通过随机数表法,将患者分为观察组和对照组,每组78例。观察组实行盐酸羟考酮缓释片治疗,对照组实行盐酸吗啡缓释片治疗,对比两组疼痛缓解情况、用药相关指标以及不良反应发生情况。结果观察组癌痛缓解有效率与对照组相比,差异无统计学意义(P>0.05)。观察组患者疼痛控制稳定时间,疼痛爆发次数与解救药物使用记录均低于对照组,差异有统计学意义(P均<0.05)。观察组的不良反应发生率(7.69%)低于对照组(19.23%),差异有统计学意义(χ^(2)=4.457,P<0.05)。结论给予晚期癌痛患者盐酸羟考酮缓释片作为镇痛措施,效果显著,且镇痛稳定、起效迅速,不良反应作用少。Objective To investigate the pharmacologic effect of oxycodone hydrochloride sustained-release tablets in the treatment of advanced cancer pain.Methods A total of 156 patients with advanced cancer pain admitted to Boai Hospital in Rugao from August 2020 to July 2023 were selected as observation objects.The patients were divided into observation group and control group by random number table method,with 78 cases in each group.The observation group was treated with oxycodone hydrochloride sustained-release tablets,while the control group was treated with morphine hydrochloride sustained-release tablets.The pain relief,drug use related indexes and the occurrence of ad⁃verse reactions were compared between the two groups.Results There was no significant difference between observa⁃tion group and control group in cancer pain relief efficiency(P>0.05).The stable time of pain control,the number of pain outbreaks and the use of relief drugs in the observation group were lower than those in the control group,the dif⁃ferences were statistically significant(all P<0.05).The incidence of adverse reactions in observation group(7.69%)was lower than that in control group(19.23%),and the difference was statistically significant(χ^(2)=4.457,P<0.05).Conclusion For patients with advanced cancer pain,oxycodone hydrochloride sustained-release tablets are intro⁃duced as analgesic measures,which have remarkable efficacy,stable analgesia,rapid effect and few adverse reactions,and are worthy of clinical application.

关 键 词：盐酸羟考酮缓释片 晚期癌痛 药学作用 

分 类 号：R4[医药卫生—临床医学]