支气管动脉灌注白蛋白紫杉醇+洛铂化疗联合动脉栓塞治疗晚期非小细胞肺癌的临床效果  

Clinical Effect of Bronchial Artery Perfusion with Albumin Paclitaxel+Lo⁃baplatin Chemotherapy Combined with Arterial Embolization for Ad⁃vanced Non-small Cell Lung Cancer

作　　者：纪永棋 焦言 张芳芳 JI Yongqi;JIAO Yan;ZHANG Fangfang(Department of Comprehensive Intervention,Caoxian People's Hospital,Heze,Shandong Province,274400 China)

机构地区：[1]曹县人民医院综合介入科,山东菏泽274400

出　　处：《系统医学》2024年第10期187-189,198,共4页Systems Medicine

摘　　要：目的探讨晚期非小细胞肺癌(Non-small Cell Lung Cancer,NSCLC)患者采用支气管动脉灌注白蛋白紫杉醇(Nanoparticle Albumin Bound Paclitaxel,NAB-PTX)+洛铂(Lobaplatin,LBP)化疗联合动脉栓塞治疗的临床效果。方法选取2021年2月—2023年10月曹县人民医院收治的40例晚期NSCLC患者为研究对象,以随机数表法分为研究组和对照组,各20例。两组均给予动脉栓塞治疗,对照组给予支气管动脉灌注NAB-PTX+顺铂(Cisplatin,DDP)化疗,研究组给予支气管动脉灌注NAB-PTX+LBP化疗,比较两组近期疗效及血清肿瘤标志物水平。结果研究组客观缓解率为65.00%,高于对照组的30.00%,差异有统计学意义(χ^(2)=4.912,P<0.05)。治疗后两组糖类抗原125、癌胚抗原水平均下降,且研究组较对照组更低,差异有统计学意义(P均<0.05)。结论支气管动脉灌注NAB-PTX+LBP化疗联合动脉栓塞应用于晚期NSCLC患者治疗中,可以提高临床疗效,降低血清肿瘤标志物水平。Objective To explore the clinical effect of advanced non-small cell lung cancer(NSCLC)patients treated with Nanoparticle Albumin Bound Paclitaxel(NAB-PTX)+lobaplatin(LBP)chemotherapy combined with arterial em⁃bolization.Methods A total of 40 patients with advanced NSCLC admitted to Caoxian People's Hospital from Febru⁃ary 2021 to October 2023 were selected as the study objects and were divided into a study group and a control group with 20 cases in each group by random number table method.Both groups were given arterial embolization treatment.The control group was given bronchial arterial infusion NAB-PTX+cisplatin(DDP)chemotherapy,and the study group was given bronchial arterial infusion NAB-PTX+LBP chemotherapy.Recent efficacy and serum tumor markers were compared between the two groups.Results The objective response rate was 65.00%in the study group,higher than 30.00%in the control group,the difference was statistically significant(χ^(2)=4.912,P<0.05).The levels of carbohy⁃drate antigen 125 and carcinoembryonic antigen decreased in both groups after treatment,and were lower in the study group compared to the control group,the differences were statistically significant(all P<0.05).Conclusion Bronchial artery perfusion NAB-PTX+LBP chemotherapy combined with arterial embolization can improve clinical efficacy and reduce serum tumor marker levels when applied in the treatment of advanced NSCLC patients.

关 键 词：支气管动脉灌注 白蛋白紫杉醇 洛铂 动脉栓塞 晚期非小细胞肺癌 

分 类 号：R4[医药卫生—临床医学]