二氧化碳通气当量截距、C3a和炎症因子水平对COPD患者疾病加重风险的预测价值  

The Predictive Value of Carbon Dioxide Ventilation Equivalent Intercept,C3a,and Inflammatory Factor Levels for the Risk of Disease Exacerbation in COPD Patients

作　　者：王龙[1] 陈玉 赵珂 WANG Long;CHEN Yu;ZHAO Ke(Department of Respiratory and Critical Care Medicine,Anyang City People's Hospital,Anyang Henan 455000)

机构地区：[1]安阳市人民医院呼吸与危重症医学科,河南安阳455000 [2]安阳市人民医院医务科,河南安阳455000

出　　处：《医学临床研究》2024年第6期868-870,874,共4页Journal of Clinical Research

摘　　要：【目的】探讨二氧化碳通气当量截距、C3a和炎症因子水平对慢性阻塞性肺疾病(COPD)患者疾病加重风险的预测价值。【方法】选取2020年2月至2023年2月在本院首次被诊断为COPD的100例患者,随访1年,根据疾病加重次数将COPD患者分为加重组(疾病加重次数≥2次/年,n=65)和稳定组(疾病加重次数<2次/年,n=35)。比较两组二氧化碳通气当量截距、C3a水平、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平,采用受试者工作特征(ROC)曲线和Logistic回归分析二氧化碳通气当量截距、C3a及炎症因子水平对COPD疾病加重风险的预测价值。【结果】加重组吸烟占比、二氧化碳通气当量截距及IL-6、TNF-α、CRP水平均高于稳定组,血清C3a水平低于稳定组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示:二氧化碳通气当量截距、C3a、IL-6、TNF-α、CRP及联合预测COPD疾病加重风险的曲线下面积(AUC)分别为0.786、0.746、0.851、0.848、0.833、0.975。Logistic回归模型分析结果显示:二氧化碳通气当量截距高、血清C3a水平低及炎症因子水平高是导致COPD疾病加重的独立危险因素(P<0.05)。【结论】二氧化碳通气当量截距、血清C3a和炎症因子水平对COPD疾病加重风险具有一定的预测价值。【Objective】To explore the predictive value of carbon dioxide ventilation equivalent intercept,C3a,and inflammatory factor levels on the risk of disease exacerbation in patients with chronic obstructive pulmonary disease(COPD).【Methods】A total of 100 patients diagnosed with COPD for the first time in our hospital from February 2020 to February 2023 were selected and followed up for 1 year.COPD patients were divided into two groups based on the number of disease exacerbations:recombinant group(disease exacerbation≥2 times/year,n=65)and stable group(disease exacerbation<2 times/year,n=35).The carbon dioxide ventilation equivalent intercept,C3a level,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]levels were compared between the two groups.The predictive value of carbon dioxide ventilation equivalent intercept,C3a,and inflammatory factor levels on the risk of exacerbation of COPD was analyzed using receiver operating characteristic(ROC)curves and logistic regression.【Results】The proportion of smoking,carbon dioxide ventilation equivalent intercept,and levels of IL-6,TNF-α,and CRP in the control group were all higher than those in the stable group,while serum C3a levels were lower than those in the stable group,with statistical significance(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)for carbon dioxide ventilation equivalent intercept,C3a,IL-6,TNF-α,CRP,and combined prediction of the risk of exacerbation of COPD were 0.786,0.746,0.851,0.848,0.833,and 0.975,respectively.The results of the logistic regression model analysis showed that high carbon dioxide ventilation equivalent intercept,low serum C3a levels,and high levels of inflammatory factors were independent risk factors for exacerbation of COPD(P<0.05).【Conclusion】Carbon dioxide ventilation equivalent intercept,serum C3a,and inflammatory factor levels have certain predictive value for the risk of exacerbation of COPD.

关 键 词：肺疾病 慢性阻塞性 血气监测 经皮 补体C3a 白细胞介素6 肿瘤坏死因子Α 

分 类 号：R563[医药卫生—呼吸系统]