补肾安胎饮联合小剂量阿司匹林及低分子肝素治疗复发性流产患者的疗效观察  

Observation on Curative Effect of Bushen Antai Decoction Combined with Small-Dose Aspirin and Low-Molecular-Weight Heparin on Patients with Recurrent Spontaneous Abortion

作　　者：王培培 徐应利 李伟莉[1] WANG Pei-pei;XU Ying-li;LI Wei-li(Gynaecology Department,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei Anhui 230012;Gynaecology Department,Lu′an Hospital of Traditional Chinese Medicine,Lu′an Anhui 237005)

机构地区：[1]安徽中医药大学第一附属医院妇科,安徽合肥230012 [2]六安市中医院妇科,安徽六安237005

出　　处：《世界中西医结合杂志》2024年第6期1152-1156,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：2022年全国名老中医药专家传承工作室建设项目(国中医药人教函(2022)75号)。

摘　　要：目的探讨补肾安胎饮联合小剂量阿司匹林、低分子肝素治疗复发性流产(Recurrent spontaneous abortion,RSA)患者的临床疗效。方法选取2020年1月—2023年1月期间于安徽中医药大学第一附属医院和六安市中医院就诊的RSA患者92例,依据随机数字表法分为对照组和治疗组,每组各46例。对照组给予常规小剂量阿司匹林、低分子肝素治疗,治疗组在对照组基础上联合补肾安胎饮治疗。治疗2个疗程后,观察比较两组患者活产率及不良反应情况,治疗前后中医临床证候评分,性激素[人绒毛膜促性腺激素(β-humanchorionic gonadotrophin,β-HCG)、雌二醇(Estradiol,E_(2))、孕酮(Progesterone,P)]水平及免疫功能指标[人干扰素-γ(Interferon-γ,INF-γ)、白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-4(Interleukin-4,IL-4)]变化。结果治疗后治疗组RSA患者总活产率91.3%(42/46)明显高于对照组82.6%(38/46),差异有统计学意义(P<0.05)。治疗后两组RSA患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.01);且治疗组中医证候评分明显低于对照组,差异有统计学意义(P<0.01)。治疗后两组RSA患者性激素β-HCG、E_(2)及P水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组性激素β-HCG、E_(2)及P水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组RSA患者外周血INF-γ、IL-2水平均较治疗前降低,IL-4水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组INF-γ、IL-2水平均明显低于对照组,IL-4水平明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率17.39%(8/46)与对照组21.74%(10/46)比较,差异无统计学意义(P>0.05)。结论补肾安胎饮联合小剂量阿司匹林、低分子肝素可提高临床保胎率,降低中医证候评分,改善激素水平及免疫功能,且具有相当的安全性,值得推荐使用。Objective To explore the curative effect of Bushen Antai Decoction combined with small-dose aspirin and low-molecular-weight heparin on patients with recurrent spontaneous abortion(RSA).Methods A total of 92 patients with RSA admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine and the Lu'an Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were selected.They were randomly divided into a control group and a treatment group by using a random number table method,with 46 patients in each group.The control group was treated with conventional small-dose aspirin and low-molecular-weight heparin,while the treatment group was treated with Bushen Antai Decoction on the basis of the control group.After treatment for two courses,live birth rate,adverse reactions,traditional Chinese medicine(TCM)clinical syndrome score before and after treatment,sex hormone levels[humanchorionic gonadotrophin(β-HCG),estradiol(E_(2)),and progesterone(P)],immune function indicators[human interferon-γ(INF-γ),interleukin-2(IL-2),and interleukin-4(IL-4)]of the two groups were observed and compared.Results After treatment,the total birth rate of patients with RSA in the treatment group was 91.3%(42/46),higher than that in the control group of 82.6%(38/46),with a statistically significant difference(P<0.05).After treatment,the TCM syndrome scores of patients with RSA in the two groups decreased(P<0.01),and the TCM syndrome score of the treatment group was lower than that of the control group(P<0.01).After treatment,the levels of sex hormones β-HCG,E_(2),and P of patients with RSA in the two groups were higher(P<0.05),and the levels of sex hormones β-HCG,E 2,and P of the treatment group were higher than those of the control group(P<0.05).After treatment,the levels of INF-γ and IL-2 in the peripheral blood of patients with RSA in the two groups were lower,and the levels of IL-4 were higher(P<0.05).In addition,INF-γ and IL-2 levels in the treatment group were significantly lower than those i

关 键 词：补肾安胎饮 复发性流产 阿司匹林 低分子肝素 

分 类 号：R714.21[医药卫生—妇产科学]