补肾安胎方治疗肾虚型早期先兆流产患者的临床疗效及对其Th1/Th2相关因子、Th17/Treg细胞平衡的影响  

Clinical Efficacy of Bushen Antai Formula in Treating Early Threatened Miscarriage of Kidney Deficiency Type and Its Influence on Th1/Th2-Related Factors and Th17/Treg Cell Balance

作　　者：王昀[1] 齐丹[1] 周雪[1] WANG Yun;QI Dan;ZHOU Xue(Nanjing Women and Children′s Healthcare Hospital,Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University,Nanjing Jiangsu 210004)

机构地区：[1]南京医科大学附属妇产医院南京市妇幼保健院,江苏南京210004

出　　处：《世界中西医结合杂志》2024年第6期1157-1161,1167,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目资助(81971386)。

摘　　要：目的探讨补肾安胎方治疗肾虚型早期先兆流产临床疗效及对Th1/Th2相关因子、Th17/Treg细胞平衡的影响。方法选取2021年1月—2022年12月期间南京市妇幼保健院收治的126例肾虚型早期先兆流产患者为研究对象,按随机数字表法分为对照组和观察组,每组各63例。对照组给予口服地屈孕酮治疗,观察组在对照组基础上增加补肾安胎方治疗。连续治疗14 d后,观察比较两组患者临床疗效及治疗前后中医证候积分、性激素[人绒毛膜促性腺激素(Human chorionic gonadotropin,β-HCG)、孕酮(Progesterone,P)、雌二醇(Estradiol,E_(2))、卵泡刺激素(Follicle stimulating hormone,FSH)]、Th1/Th2相关因子[白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-10(Interleukin-10,IL-10)、干扰素-γ(Interferonγ,INF-γ)]、Th17/Treg水平。结果治疗后观察组临床总有效率92.06%(58/63)明显高于对照组79.37%(50/63),差异有统计学意义(P<0.05)。治疗后两组患者阴道流血时间、出血量、小腹疼痛或坠胀、腰酸痛、头晕耳鸣、夜尿频数、两膝酸软积分及总积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组阴道流血时间、出血量、小腹疼痛或坠胀、腰酸痛、头晕耳鸣、夜尿频数、两膝酸软积分及总积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者性激素β-HCG、P、E_(2)、FSH水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组性激素β-HCG、P、E_(2)、FSH水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清IL-4、IL-10水平较治疗前升高,IL-2、INF-γ水平较治疗前降低,差异有统计学意义(P<0.05);且观察组IL-4、IL-10水平高于对照组,IL-2、INF-γ水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清Th17及Th17/Treg水平较治疗前降低,差异有统计学意义(P<0.05);且观察组血清Th17及Th17/TregObjective To investigate the clinical efficacy of Bushen Antai formula in the treatment of kidney deficiency type early threatened miscarriage and its influence on Th1/Th2 related factors and Th17/Treg cell balance.Methods A total of 126 patients with early threatened miscarriage of kidney deficiency type treated at our hospital from January 2021 to December 2022 were selected as the study object and randomly divided into an observation group and a control group,with 63 cases in each group.The control group was given oral dydrogesterone treatment,and the observation group was given Bushen Antai formula in addition to dydrogesterone.After continuous treatment for 14 days,the clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,sex hormones[human chorionic gonadotropin(β-HCG),progesterone(P),estradiol(E_(2)),follicle stimulating hormone(FSH)],Th1/Th2-related factors[interleukin-2(IL-2),IL-4,IL-10,interferonγ(INF-γ)]and Th17/Treg level before and after treatment were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 92.06%(58/63),which was significantly higher than that of the control group(79.37%,50/63),and the difference was statistically significant(P<0.05).After treatment,both groups showed a decrease in vaginal bleeding time,blood loss,lower abdominal pain or distension,lumbar soreness,dizziness and tinnitus,nocturnal frequency of urination,and the score and total score of both knees compared to before treatment,with statistically significant differences(P<0.05).Moreover,all indexes in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of sex hormones β-HCG,P,E_(2) and FSH in 2 groups were higher than before treatment,with statistically significant differences(P<0.05).The indexes in the observation group were higher than those in the control group,statistically significant differences(P<0.05).After treatment,both groups showed an incre

关 键 词：补肾安胎方 肾虚型 早期 先兆流产 

分 类 号：R714.21[医药卫生—妇产科学]