益元稳胎固冲补肾方对脾肾亏虚证先兆流产患者保胎效果及孕三项的影响  

Effect of Yiyuan Wentai Guchong Bushen Formula on Fetus Protection and Three Pregnancy Items of Patients with Threatened Abortion of Spleen and Kidney Deficiency Syndrome

作　　者：丘远婵 刘玉[1] 管雁丞[1] QIU Yuan-chan;LIU Yu;GUAN Yan-cheng(Obstetrics and Gynecology Department,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen Guangdong 518000)

机构地区：[1]深圳市中医院妇产科,广东深圳518000

出　　处：《世界中西医结合杂志》2024年第6期1201-1206,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省自然科学基金项目(2021A030313406)。

摘　　要：目的探讨益元稳胎固冲补肾方对脾肾亏虚证先兆流产患者保胎效果及内分泌激素的影响。方法选取2021年3月—2022年8月期间深圳市中医院妇产科收治的90例先兆流产患者,依据简单随机数字表法分为对照组和研究组,每组各45例。对照组采取常规治疗,研究组在对照组基础上加用益元稳胎固冲补肾方,均治疗14 d。观察比较两组患者临床疗效、保胎效果,治疗前后中医证候积分、孕三项[雌二醇(Estradiol,E_(2))、孕酮(Progesterone,P)、人绒毛膜促性腺素(Human chorionic gonadotropin,HCG)]水平、炎症因子[白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-4(Interleukin-4,IL-4)、干扰素-γ(Interferon-gamma,IFN-γ)]水平及不良反应发生情况。结果治疗后研究组临床总有效率95.56%(43/45)明显高于对照组82.22%(37/45),差异有统计学意义(P<0.05)。治疗后研究组足月妊娠率82.22%(37/45)明显高于对照组60.00%(27/45),早产率13.33%(6/45)明显低于对照组33.33%(15/45),差异有统计学意义(P<0.05)。治疗后两组患者腰膝酸软、腹痛、阴道流血及大便稀溏、夜尿频多、腹胀纳差、面色萎黄分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者内分泌激素E_(2)、P、HCG水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组内分泌激素E_(2)、P、HCG水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者炎症因子血清IL-2、IFN-γ水平均较治疗前降低,IL-4水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组血清IL-2、IFN-γ水平均明显低于对照组,IL-4水平明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未见药物相关不良反应发生。结论常规干预基础上采取益元稳胎固冲补肾方治疗脾肾亏虚证先兆流产,可有效缓解临床症状,调节孕三项�Objective To explore the effect of Yiyuan Wentai Guchong Bushen Formula on fetus protection and endocrine hormones of patients with threatened abortion of spleen and kidney deficiency syndrome.Methods A total of 90 patients with threatened abortion admitted to the Obstetrics and Gynecology Department,Shenzhen Hospital of Traditional Chinese Medicine,from March 2021 to August 2022 were selected and divided into a study group(n=45)and a control group(n=45)based on a simple random number table method.The control group received routine treatment,while the study group received Yiyuan Wentai Guchong Bushen Formula on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy,fetus protection effect,traditional Chinese medicine(TCM)syndrome score before and after treatment,three pregnancy items[estradiol(E2),progesterone(P),and human chorionic gonadotropin(HCG)]levels,inflammatory factors[interleukin-2(IL-2)and interleukin-4(IL-4)],interferon-gamma(IFN-γ)level,and occurrence of adverse reactions of the two groups were compared.Results The total effective rate of the study group(95.56%,43/45)was higher than that of the control group(82.22%,37/45),and the difference was statistically significant(P<0.05).After treatment,the full-term pregnancy rate(82.22%,37/45)in the study group was higher than that in the control group(60.00%,27/45),and the preterm birth rate(13.33%,6/45)was lower than that in the control group(33.33%,15/45)(P<0.05).After treatment,the scores of soreness and weakness of the waist and knees,abdominal pain,vaginal bleeding,loose stool,frequent nocturnal urination,poor abdominal distension,and sallow complexion in both groups were lower(P<0.05).In addition,the TCM syndrome score of the study group was significantly lower than that of the control group(P<0.05).After treatment,the levels of E2,P,and HCG in the two groups increased(P<0.05),and levels in the study group were higher than those in the control group(P<0.05).After treatment,the levels of serum IL-2 and IFN-γin the t

关 键 词：益元稳胎固冲补肾方 先兆流产 脾肾亏虚 孕三项 

分 类 号：R714.21[医药卫生—妇产科学]