健脾祛风汤联合皮炎洗剂治疗特应性皮炎疗效研究  

Curative effect study on Jianpi Qufeng decoction combined with dermatitis lotion on atopic dermatit

作　　者：陈雪[1] 李红敏[1] 刘青 施建新[1] CHEN Xue;LI Hongmin;LIU Qing;SHI Jianxin(Affiliated Hospital of Nanjing Univercity of Traditional Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《陕西中医》2024年第7期902-904,941,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81903968)。

摘　　要：目的:研究健脾祛风汤联合皮炎洗剂治疗特应性皮炎的效果及对免疫球蛋白E(IgE)和白介素-4(IL-4)的影响。方法:收集120例特应性皮炎患者临床资料,并开展回顾性对比研究。观察组60例,行健脾祛风汤联合皮炎洗剂;对照组60例,行皮炎洗剂干预。比较两组患者治疗效果,记录两组患者治疗前后皮肤屏障功能[皮脂含量、角质层含水量及经皮水分丢失(TEWL)含量]、血清因子(IL-4、IgE)水平及生活质量评分。结果:观察组患者整体疗效较对照组显著提高(P<0.05)。治疗后观察组患者皮脂含量和角质层含水量均高于对照组,TEWL低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清IL-4和IgE较治疗前均显著降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组皮肤病生活质量指数(DLQI)和特应性皮炎积分(SCORAD)较治疗前均显著降低,且观察组低于对照组(P<0.05)。结论:健脾祛风汤联合皮炎洗剂用于特应性皮炎效果显著,有助于保护皮肤屏障功能,减轻临床症状,改善患者生活质量。Objective:Study on the effect of Jianpi Qufeng decoction combined with dermatitis lotion in the treatment of atopic dermatitis and its influence on immunoglobulin E(IgE)and interleukin-4(IL-4).Methods:The clinical dataes of 120 patients with atopic dermatitis were collected and retrospective comparative study was conducted.The observation group had 60 cases,who treated with Jianpi Qufeng decoction combined with dermatitis lotion.60 cases in the control group received intervention with dermatitis lotion.The treatment effects of two groups were compared,the skin barrier function[sebum content,stratum corneum moisture content,and transdermal water loss(TEWL)],serum factors(IL-4、IgE)levels and quality of life scores of two groups of patients before and after treatment were recorded.Results:The overall therapeutic effect of the observation group patients were significantly improved,which compared to the control group(P<0.05).After treatment,the sebum content and stratum corneum water content of the observation group were higher than those in the control group,and the TEWL was lower than that in the control group,differences statistically significant(P<0.05).After treatment,the serum IL-4 and IgE levels in the two groups of patients were significantly reduced,which compared to before treatment,and the observation group were lower than the control group,differences statistically significant(P<0.05).After treatment,the dermatology life quality index(DLQI)and scoring atopic dermatitis index(SCORAD)of the two groups were significantly reduced,which compared to before treatment,and the observation group were lower than the control group(P<0.05).Conclusion:Combination of Jianpi Qufeng decoction and dermatitis lotion has significant effect on atopic dermatitis.It help to protect skin barrier function,alleviate clinical symptoms and improve quality of life.

关 键 词：特应性皮炎 健脾祛风汤 皮炎洗剂 皮肤屏障功能 白介素-4 免疫球蛋白E 

分 类 号：R246.7[医药卫生—针灸推拿学]