逍遥散加味联合曲安奈德治疗口腔扁平苔藓肝郁血瘀证疗效研究  

Curative effect study on Xiaoyao powder combined with triamcinolone acetonide in treatment oral lichen planus of Ganyu Xueyu

作　　者：卓思源  杨小如 何昕 ZHUO Siyuan;NICOLA Cirillo;YANG Xiaoru;HE Xin(The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]墨尔本大学口腔健康学院,墨尔本3000 [3]山南市人民医院,西藏山南856000 [4]安徽医科大学附属口腔医院,安徽合肥230036

出　　处：《陕西中医》2024年第7期918-921,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：西藏自治区自然科学基金资助项目[XZ2019ZR-ZY39(Z)]。

摘　　要：目的:探讨逍遥散加味联合曲安奈德治疗口腔扁平苔藓(OLP)肝郁血瘀证的疗效及对唾液炎症因子的影响。方法:选取84例OLP肝郁血瘀证患者按照随机数字表法分为观察组(n=42)和对照组(n=42)。对照组予曲安奈德注射液1 ml混合等量2%盐酸利多卡因注射液于病损边缘局部注射,观察组在对照组治疗基础上予以逍遥散加味治疗,治疗8周后比较两组的临床疗效、症状评分、唾液炎症因子、免疫功能及不良反应发生情况,记录治疗后6个月的复发情况。结果:观察组临床总有效率为92.86%高于对照组的76.19%(P<0.05)。观察组治疗后主观和客观症状评分低于对照组(P<0.05)。观察组治疗后唾液白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。观察组治疗后CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平明显低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。观察组复发率明显低于对照组(P<0.05)。结论:逍遥散加味联合曲安奈德可有效提高OLP肝郁血瘀证患者的治疗效果,进一步缓解患者的临床症状,降低复发率及唾液炎症因子表达水平,提高机体免疫功能,安全性较好。Objective:To explore curative effect of modified Xiaoyao powder combined with triamcinolone acetonide in treatment of oral lichen planus(OLP)with Ganyu Xueyu syndrome and its effect on salivary inflammatory factors.Methods:Eighty-four patients with OLP of Ganyu Xueyu were selected and divided into observation group(n=42)and control group(n=42)according to random number table method.The control group were treated with triamcinolone acetonide injection 1 ml mixed with the same amount of 2%lidocaine hydrochloride injection on edge of the lesion.The observation group were treated with Xiaoyao powder on the basis of the control group.After 8 weeks of treatment,clinical efficacy,symptom score,salivary inflammatory factors,immune function and adverse reactions of the two groups were compared,and recurrence of 6 months after treatment were recorded.Results:The total effective rate of the observation group was 92.86%higher than 76.19%of the control group(P<0.05).The scores of subjective and objective symptoms in the observation group were significantly lower than those in the control group(P<0.05).The levels of salivary interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in the control group(P<0.05).After treatment,levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were significantly higher than those in the control group,and level of CD8^(+)was significantly lower than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was significantly lower than that in the control group(P<0.05).Conclusion:Modified Xiaoyao powder combined with triamcinolone acetonide can effectively improve the therapeutic effect of OLP patients with Ganyu Xueyu,further alleviate clinical symptoms of patients,reduce recurrence rate and level of salivary inflammatory factors,improve immune function of the body and better saf

关 键 词：口腔扁平苔藓 肝郁血瘀 逍遥散加味 曲安奈德 唾液炎症因子 免疫功能 不良反应 

分 类 号：R246.83[医药卫生—针灸推拿学]