益气健脾方联合蟾酥注射液对晚期胃癌T淋巴细胞亚群平衡及胃肠激素的影响  

Effects of Yiqi Jianpi Recipe(益气健脾方)Combined with Toad Venom Injection on T Lymphocyte Subsets Balance and Gastrointestinal Hormones in Patients with Advanced Gastric Cancer

作　　者：赖慧 张林松 臧明轩 李建 赵福兰 LAI Hui;ZHANG Linsong;ZANG Mingxuan;LI Jian;ZHAO Fulan(Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical University,Luzhou 646000,Sichuan,China;Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100000,China)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000 [2]中国中医科学院西苑医院,北京100000

出　　处：《中华中医药学刊》2024年第7期226-230,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：四川省教育厅科研计划项目(18ZB0643)。

摘　　要：目的分析益气健脾方联合蟾酥注射液治疗晚期胃癌效果及对患者T淋巴细胞亚群平衡及胃肠激素的影响。方法采取随机数字表法将纳入的85例晚期胃癌患者(2021年3月—2022年12月收治)分为两组,对照组患者(42例)采取化疗治疗,中医方案组(43例)患者化疗治疗基础上结合益气健脾方及蟾酥注射液治疗,指标观察:各组疗效、治疗不良反应、中医证候积分(上腹痛及恶心呕吐、食欲减退、消瘦乏力、呕血黑便等)变化及肿瘤标志物水平变化、炎症因子指标变化及T淋巴细胞亚群指标变化、胃肠激素指标变化、肿瘤生活质量评分标准(Karnofsky performance status, KPS)变化。结果对照组与中医方案组治疗总有效率比较[52.38%(22/42)vs 76.74%(33/43)],P<0.05;中医方案组患者不良反应少于对照组(P<0.05);各组治疗前中医证候积分(上腹痛、恶心呕吐、食欲减退、消瘦乏力、呕血黑便等)、糖类抗原19-9(carbohydrate antigen 19-9,CA19-9)及糖类抗原72-4(carbohydr ateantigen72-4,CA72-4)、癌胚抗原(carcinoembryonic antigen, CEA)等肿瘤标志物水平、白介素-6(interleukin 6,IL-6)、白介素-8(interleukin 8,IL-8)与肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)等炎症因子指标、CD_(4)^(+)T淋巴细胞(cluster of differentiation 4,CD_(4)^(+))、CD_(8)^(+)T淋巴细胞(cluster of differentiation 8,CD_(8)^(+))、CD_(4)^(+)/CD_(8)^(+)等T淋巴细胞亚群指标、胃蛋白酶原Ⅰ(pepsinogenⅠ,PGⅠ)与胃蛋白酶Ⅱ(pepsinogenⅡ,PGⅡ)、胃液素(gastrin, GAS)等胃肠激素、KPS评分等指标比较,均P>0.05;治疗后各组患者中医证候积分(上腹痛、恶心呕吐、食欲减退、消瘦乏力、呕血黑便等)、CA19-9及CA72-4、CEA、IL-6、IL-8及TNF-α水平均降低,中医方案组比对照组更低(P<0.05);对照组患者治疗后CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)指标无显著变化(P>0.05),中医方案组CD_(4)^(+)上升,CD_(8)^(+)下降,CD_(4)^(+)/CD_(8)^(+)指标�Objective To analyze the effects of Yiqi Jianpi Recipe(益气健脾方)combined with toad venom injection in the treatment of advanced gastric cancer and the effects on the balance of T lymphocyte subsets and gastrointestinal hormones in patients.Methods In this study,85 patients with advanced gastric cancer(admitted from March 2021 to December 2022)were divided into two groups by random number table method.The patients in the control group(42 cases)were treated with chemotherapy and those in the traditional Chinese medicine regimen group(43 cases)were treated with Yiqi Jianpi Recipe and toad venom injection on the basis of chemotherapy treatment.In each group,the changes in efficacy,adverse reactions,TCM syndrome scores(epigastric pain,nausea and vomiting,loss of appetite,emaciation,hematemesis and black stool,etc.),the changes in tumor markers,inflammatory factors,T lymphocyte subsets and gastrointestinal hormones,and the changes in tumor quality of life(Karnofsky performance status,KPS)were observed.Results The total effective rate between the control group and the traditional Chinese medicine regimen group was significant[52.38%(22/42)vs 76.74%(33/43)](P<0.05).The adverse reactions in traditional Chinese medicine regimen group were less than those in the control group(P<0.05).The levels of carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen72-4(carbohydr ateantigen72-4)and other tumor markers,the levels of interleukin 6(IL-6),interleukin 8(IL-8),tumor necrosis factor(TNF-α)and other indicators of inflammatory factors,the levels of CD_(4)^(+) T lymphocytes(cluster of differentiation 4,CD_(4)^(+)),CD_(8)^(+) T lymphocyte subsets(cluster of differentiation 8,CD_(8)^(+)),CD_(4)^(+)/CD_(8)^(+) and other T lymphocyte subsets,the levels of pepsinogenI(PGI),pepsinogenⅡ(PGⅡ)and gastrin(GAS),KPS score and other indexes in both groups before treatment were not significant(all P>0.05).After treatment,TCM syndrome scores(epigastric pain,nausea and vomiting,loss of appetite,emaciation,hematemesis and black stool

关 键 词：晚期胃癌 益气健脾方 蟾酥注射液 T淋巴细胞亚群 胃肠激素 不良反应 疗效 

分 类 号：R273.352[医药卫生—中西医结合]