养元益肾散合并低温透析治疗血液透析相关性低血压临床观察  

Clinical Observation of Yangyuan Yishen Powder(养元益肾散)Combined with Low Temperature Dialysis in Treatment of Hemodialysis Related Hypotension

作　　者：李智全[1] 姚涛[2] 张靖芳 LI Zhiquan;YAO Tao;ZHANG Jingfang(First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;School of Traditional Chinese Medicine(Zhongjing College),Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;Huiji District People's Hospital,Zhengzhou 450053,Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000 [2]河南中医药大学中医学院(仲景学院),河南郑州450046 [3]郑州市惠济区人民医院,河南郑州450053

出　　处：《中华中医药学刊》2024年第7期230-233,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省卫生健康委会中医药科学研究专项(20-21ZY2175)。

摘　　要：目的研究养元益肾散合并低温透析治疗血液透析相关性低血压的效果。方法选择2021年3月—2022年10月医院诊治的血液透析相关性低血压患者98例为研究对象,根据随机数表法均分为两组,每组49例,对照组给予常规西药干预,观察组给予养元益肾散合并低温透析治疗干预。观察并比较两组患者的血压、心率,中医症状积分,透析充分性指标,不良反应发生情况。结果干预前,两组患者的舒张压、收缩压、平均动脉压、心率比较差异均无统计学意义(P>0.05);干预后,观察组舒张压、收缩压、平均动脉压显著高于对照组,心率显著低于对照组,差异均有统计学意义(P<0.05)。干预前,两组患者的主要中医症状疲惫乏力、口干、皮肤干燥、头晕积分比较差异均无统计学意义(P>0.05);干预后,观察组以上各症状积分显著低于对照组(P<0.05)。干预前,两组患者尿素清除指数(Urea clearance index, Kt/V)、平均时间尿素值(Time-average concentration of urea, TACurea)、C-反应蛋白(C-reactive protein, CRP)及尿素下降率(Urea reduction ratio, URR)差异均无统计学意义(P>0.05);干预后,观察组KT/V、TACurea、CRP及URR均显著高于对照组(P<0.05)。观察组、对照组不良反应发生率分别为12.24%(6/49)、16.33%(8/49),差异无统计学意义(P>0.05)。结论养元益肾散合并低温透析治疗血液透析相关性低血压的效果良好,能够有效改善血压水平,降低心率,减轻患者症状,增强透析充分性,并且安全性可靠,是可行性方案。Objective To study the effect of Yangyuan Yishen Powder(养元益肾散)combined with low temperature dialysis on hemodialysis related hypotension.Methods A total of 98 patients with hemodialysis-related hypotension diagnosed and treated in the hospital from March 2021 to October 2022 were selected as the research objects.According to the random number table method,they were divided into two groups,49 cases in each group.The control group was given routine western medicine prevention and treatment measures,and the observation group was given Yangyuan Yishen Powder combined with low temperature dialysis treatment intervention.The blood pressure,heart rate,TCM symptom score,dialysis adequacy index and adverse reactions were observed and compared between the two groups.Results Before intervention,there was no significant difference in diastolic blood pressure,systolic blood pressure,mean arterial pressure or heart rate between the two groups(P>0.05).After intervention,the diastolic blood pressure,systolic blood pressure and mean arterial pressure in the observation group were significantly higher than those in the control group,and the heart rate was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).Before intervention,there was no significant difference in the scores of fatigue,dry mouth,dry skin or dizziness between the two groups(P>0.05).After intervention,the scores of the above symptoms in the observation group were significantly lower than those in the control group(P<0.05).Before intervention,there was no significant difference in urea clearance index(Kt/V),time-average concentration of urea(TACurea),C-reactive protein(CRP)and urea reduction ratio(URR)between the two groups(P>0.05).After intervention,the values of KT/V,TACurea,CRP and URR in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 12.24%(6/49)and that in the control group was 16.33%(8/49)an

关 键 词：血液透析 透析相关性低血压 低温 养元益肾散 

分 类 号：R255.7[医药卫生—中医内科学]