海洋真菌来源杂萜类化合物的研究进展  

Research Progress in Meroterpenoids Derived from Marine Fungi

作　　者：吴晓惠 陈彬彬 黄迎 王玉琴 陈钟情 黄晓源 唐灵芝 洪璇 WU Xiaohui;CHEN Binbin;HUANG Ying;WANG Yuqin;CHEN Zhongqing;HUANG Xiaoyuan;TANG Lingzhi;HONG Xuan(Xiamen Key Laboratory of Marine Medicinal Natural Products Resources,Xiamen Medical College,Xiamen 361023,China;School of Pharmacy,Fujian Medical University,Fuzhou 350122,China)

机构地区：[1]厦门医学院厦门市海洋药用天然产物资源重点实验室,福建厦门361023 [2]福建医科大学药学院,福建福州350122

出　　处：《化学与生物工程》2024年第7期1-7,17,共8页Chemistry & Bioengineering

基　　金：福建省自然科学基金面上项目(2022J011401);厦门市自然科学基金面上项目(3502Z20227227);国家级大学生创新创业训练计划项目(202212631001);福建省本科高校教育教学改革研究项目(FBJG20190201);厦门市教育科学“十三五”规划课题项目(1926)。

摘　　要：海洋真菌生活在高盐、高压、低温、弱光的独特海洋环境中,具有结构独特、代谢多样、活性显著等特点,并产生了一系列功能多样、结构新颖的次级代谢产物,是杂萜类化合物的重要来源。海洋真菌体内复杂的次生代谢途径使获得的杂萜类化合物骨架结构多样,具有抗菌、抗肿瘤、酶活性抑制等丰富的生物活性。介绍了海洋真菌来源杂萜类化合物的研究现状,并对其生物合成途径、发酵与分离方法、生物活性等进行了综述,为海洋真菌来源杂萜类化合物的后续研究提供了一定参考。Living in the unique marine environment of high salt,high pressure,low temperature,and low light,marine fungi often have the characteristics of unique structure,diverse metabolism,and remarkable activity,and can produce a series of secondary metabolites with diverse functions and novel structures,which are important sources of meroterpenoids.The in vivo complex secondary metabolic pathways of marine fungi lead to the diversity of the backbone structures of the produced meroterpenoids,which have rich biological activities such as antibacterial,anti-tumor,and enzyme activity inhibition.In this paper,we introduce the research status of meroterpenoids derived from marine fungi,and review its biosynthetic pathways,fermentation and isolation,and biological activities.The study provides a reference for the future research of meroterpenoids derived from marine fungi.

关 键 词：杂萜类化合物 海洋真菌 生物活性 生物合成途径 

分 类 号：TQ95[化学工程]