冠状动脉周围脂肪衰减指数与CT图像重建参数的相关性研究  

Correlation between the pericoronary fat attenuation index and the CT image reconstruction parameters

作　　者：陈丽虹[1] 陈功婷 樊钢练[1] 李雅楠[1] 屈婷婷[1] 曹乐 荐志洁[1] 郭建新[1] CHEN Lihong;CHEN Gongting;FAN Ganglian;LI Yanan;QU Tingting;CAO Le;JIAN Zhijie;GUO Jianxin(Department of Medical Imaging,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院医学影像科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2024年第4期547-551,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省重点研发计划项目-一般项目(No.2023-YBSF-068);陕西省重点研发计划项目-高校联合项目(No.2020GXLH-Y-026)。

摘　　要：目的 评估冠状动脉周围脂肪衰减指数(fat attenuation index, FAI)与卷积核、迭代重建算法以及层厚等计算机断层扫描(CT)冠状动脉造影重建参数的相关性。方法 前瞻性纳入44例行CT冠状动脉造影的患者,采用以下3种参数组合进行图像重建:(1)迭代重建算法(KARL5)和层厚(0.5 mm)不变,采用4种卷积核(Soft_AA、Soft_BA、Soft_CA、Soft_DA,锐利度由低至高)重建;(2)保持卷积核(Soft_AA)和层厚(0.5 mm)不变,采用滤波反投影(filtered back projection, FBP)和迭代重建算法(KARL5)进行重建;(3)保持卷积核(Soft_AA)和迭代重建算法(KARL5)不变,采用不同层厚(0.5 mm, 1.0 mm)进行重建。经专用分析软件自动提取上述3种参数组合中所有图像的左前降支(left anterior descending artery, LAD)、左回旋支(left circumflex artery, LCX)、右冠状动脉(right coronary artery, RCA)对应的FAI。采用配对t检验、方差分析进行统计分析。结果 对于LAD、LCX和RCA:(1)不同卷积核间的差异均具有统计学意义(P<0.001),且FAI随卷积核锐利度的提高而降低;(2)相比于FBP,KARL5重建图像的FAI显著提高(P<0.001);(3)相比于0.5 mm, 1.0 mm层厚图像的FAI均显著降低(P<0.001)。结论 卷积核、迭代重建算法及图像层厚对各支冠状动脉的FAI均具有显著影响,临床应用FAI进行诊断时应充分考虑CT重建参数的影响。Objective To evaluate the relationship between the pericoronary fat attenuation index(FAI)and the image reconstruction parameters of computed tomography(CT)coronary angiography,including reconstruction kernel,iterative reconstruction algorithm and image thickness.Methods Forty-four CT coronary angiography scans were prospectively enrolled.All scans were reconstructed by three means as follows:①Four different kernels(Soft_AA,Soft_BA,Soft_CA,and Soft_DA,sharpness from low to high)as the iterative reconstruction algorithm(KARL5)and image thickness(0.5 mm)remained unchanged.②Filtered back projection(FBP)and iterative reconstruction kernel(KARL5)as the kernel and image thickness(0.5 mm)remained unchanged.③Different image thickness(0.5 mm and 1 mm)as the kernel(Soft_AA)and iterative reconstruction algorithm(KARL5)remained unchanged.The FAI of left anterior descending artery(LAD),left circumflex artery(LCX),and right coronary artery(RCA)was calculated using a dedicated software.Paired t-test and analysis of variance were used for statistical analysis.Results For LAD,LCX and RCA:①The differences of FAI among different reconstruction kernels reached statistical significance(P<0.001),and FAI decreased as the sharper kernel was used.②Compared with FBP,the FAI of KARL5-reconstructed images significantly increased(P<0.001).③Compared with 0.5 mm,the FAI of images with 1.0 mm thickness significantly decreased(P<0.001).Conclusion The kernel,iterative reconstruction algorithms,and image thickness all have a significant impact on the FAI of each coronary artery.When using FAI for clinical diagnosis,the effect of CT reconstruction parameters should be taken into account.

关 键 词：冠状动脉 粥样硬化 计算机断层扫描(CT) 重建参数 冠脉周围脂肪 

分 类 号：R445[医药卫生—影像医学与核医学]