重组狂犬病毒疫苗的研制现状  

The status in the research of recombinant Rabies virus vaccine

作　　者：李文桂[1] 陈雅棠[1] LI Wengui;CHEN Yatang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所,重庆400016

出　　处：《中国病原生物学杂志》2024年第7期859-862,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.30801052,30671835,30500423,30200239)。

摘　　要：狂犬病是一种由狂犬病毒(Rabies virus,RABV)感染导致的急性中枢神经系统病变的病毒性传染病,可用RABV的减毒株进行免疫预防。这些减毒株可诱导宿主产生细胞、体液和粘膜免疫应答,是一种理想的疫苗载体,可表达病毒、细菌和寄生虫的多种蛋白。这些疫苗包括Ⅰ型人类免疫缺陷病毒(rRABV-gag/env)、埃博拉病毒(rRABV-GP)、尼帕病毒(rRABV-G/F)、西尼罗病毒(rRABV-prME)、丙型肝炎病毒(rRABV-E2△CD4G)、水疱性口炎病毒(rRABV-GP)、淋巴细胞脉络膜炎病毒(rRABV-GPC)、犬瘟热病毒(rRABV-H/F)、猪细小病毒(rRABV-VP2)、狂犬病毒(rRABV-tRVG)、细菌(rRABV-Fla)和细粒棘球绦虫(rRABV-Eg95)等,本文就重组RABV疫苗的研制现状进行概述。Rabies caused by Rabies virus is one type of zoonotic,infectious diseases of central nervous system.it may be controled by immunoprophylaxis with attenuated RABV strains,this strains may induce the host to produce cellular,humoral and mucosal immune responses,it may become ideal vaccine vector for expressing many proteins of viruses bacteria and patasites.These vaccines include Human immunodeficiency virus(rRABV-gag/env),Ebola virus(rRABVGP),Nipah Virus(rRABV-G/F),West Nile virus(rRABV-prME),Hepatitis C virus(rRABV-E2△CD4G),Vesicular stomatitis virus(rRABV-GP),Lymphocytic choriomeningitis virus(rRABV-GPC),Canine distemper virus(rRABV-H/F),Porcine parvovirus(rRABV-VP2),Rabies virus(rRABV-tRVG),Bacteria(rRABV-Fla)and Echinococcus granulosus(rRABV-Eg95).The review outlines the status in the research of recombinant Rabies virus vaccine.

关 键 词：狂犬病毒 疫苗 综述 

分 类 号：R392[医药卫生—免疫学]