基于代谢酶的遗传药理学在儿童安全用药中的研究进展  

Advances in Pharmacogenetic Research Based on Metabolic Enzymes Related to Safe Pediatric Medication

作　　者：李真 肖婷姗 吴燕 LI Zhen;XIAO Ting-shan;WU Yan(Air Force Medical Center,Air Force Medical University,PLA,Beijing 100142,China)

机构地区：[1]空军军医大学空军特色医学中心,北京100142

出　　处：《解放军药学学报》2024年第3期282-288,共7页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：遗传药理学主要研究遗传因素对于药物代谢的影响。大多数遗传药理学研究对象为成人,基于儿童的遗传药理学研究较少。儿童和成人的生理状态差异较大,基于成人的遗传药理学研究成果是否可以用于指导儿童用药尚存争议。本文对常见药物代谢酶CYP2C9、CYP2C19、CYP2D6、CYP3A4、CYP3A5、NUDT15和TPMT基于儿童群体的遗传药理学研究进行综述,重点讨论成人和儿童的差异,为儿童安全用药提供参考。Pharmacogenetics mainly studies the influence of genetic variables on drug metabolism.Most of pharmacogenetic research has focused on adults,with only a few conducted on pediatrics.The physiological state of children and adults is considerably different,so whether findings of pharmacogenetic studies on adults are applicable to children's treatment remains controversial.This paper reviewed the pediatric evidence for pharmacogenetic associations for common drug metabolizing enzymes CYP2C9,CYP2C19,CYP2D6,CYP3A4,CYP3A5,NUDT15,and TPMT,studied the differences between adults and children,and provided reference for safe medication in children.

关 键 词：遗传药理学 药物代谢酶 儿童 安全用药 

分 类 号：R965[医药卫生—药理学]