血清25-羟基维生素D、钙、锌水平与儿童生长发育的关系  

Relationship between Levels of Serum 25-hydroxyvitamin D,Calcium,Zinc and Growth and Development of Children

作　　者：张愉愉 卢游 刘宇[1] ZHANG Yuyu;LU You;LIU Yu(Dept.of Child Care,Zigong Maternal and Child Health Hospital,Zigong Sichuan 643000;Dept.of Pediatrics,West China 2nd Hospital,Sichuan University,Chengdu Sichuan 610044,China)

机构地区：[1]自贡市妇幼保健院儿保科,四川自贡643000 [2]四川大学华西第二医院儿科,四川成都610044

出　　处：《昆明医科大学学报》2024年第7期126-131,共6页Journal of Kunming Medical University

基　　金：四川省医学(青年创新)科研课题基金资助项目(Q20016)。

摘　　要：目的观察儿童血清25-羟基维生素D钙、锌水平,并探析3项指标与儿童生长发育的关系。方法将2021年1月至2022年12月于自贡市妇幼保健院接受治疗的98例生长发育迟缓患儿纳入生长发育迟缓组,另取同期于该院体检的80例生长发育正常的儿童为生长发育正常组,对比2组血清25-羟基维生素D钙、锌水平及其他临床资料,分析血清25-羟基维生素D钙、锌水平与生长发育的关系。结果生长发育迟缓组身长/身高、体重、钙、锌、25-羟基维生素D水平低于生长发育正常组(P<0.05);经点二列相关性分析结果显示,钙、锌、25-羟基维生素D水平与儿童生长发育迟缓呈负相关(r<0,P<0.05);建立Logistic回归模型,结果显示,身长/身高(95%CI:0.673~0.824)、体重(95%CI:0.477~0.717)、钙(95%CI:0.127~0.467)、锌(95%CI:0.140~0.571)、25-羟基维生素D(95%CI:0.130~0.461)水平是儿童生长发育的保护因素(OR<1,P<0.05);绘制ROC曲线,结果显示,钙、锌、25-羟基维生素D水平对儿童生长发育具有一定预测价值(AUC=0.601、0.627、0.667),3项指标并联预测价值更高(AUC=0.808)。结论儿童生长发育状况与血清25-羟基维生素D钙、锌水平密切相关,临床应动态监测血清25-羟基维生素D钙、锌水平变化,有助于早期预测儿童生长发育状况。Objective To observe the levels of serum 25-hydroxyvitamin D,calcium and zinc in children,and explore the relationship between the three indexes and the growth and development of children.Methods From January 2021 to December 2022,98 children with growth retardation treated in Zigong Maternal and Child Health Hospital were included in the growth retardation group,and 80 children with normal growth and development were taken as the normal growth and development group.The serum 25-hydroxyvitamin D,calcium,zinc level and other clinical data of the two groups were compared,and the relationship between serum 25-hydroxyvitamin D,calcium,zinc level and growth and development was analyzed.Results The levels of body length/height,weight,calcium,zinc and 25-hydroxyvitamin D in the growth retardation group were lower than those in the normal growth development group(P<0.05).The results of point-and-column correlation analysis showed that the levels of calcium,zinc and 25-hydroxyvitamin D were negatively correlated with children's growth retardation(r<0,P<0.05).Logistic regression model was established.The results showed that the levels of Size/height(95%CI:0.673~0.824),weight(95%CI:0.477~0.717),calcium(95%CI:0.127~0.467),zinc(95%CI:0.140~0.571)and 25-hydroxyvitamin D(95%CI:0.130~0.461)were the protective factors for children's growth and development(or<1). The ROC curve was drawn.The results showed that the levels of calcium,zinc and 25-hydroxyvitamin D had certain predictive value for children's growth and development(AUC=0.601,0.627 and 0.667),and the predictive value of The three indicators are parallel was higher(AUC=0.808).Conclusion The growth and development of children is closely related to the level of serum 25-hydroxyvitamin D,calcium and zinc.Clinical monitoring of the level of serum 25-hydroxyvitamin D,calcium and zinc is helpful for early prediction of children's growth and development.

关 键 词：儿童 25-羟基维生素D 钙 锌 生长发育 

分 类 号：R446[医药卫生—诊断学]