基于近红外光谱的脑组织氧监测系统研发与验证  

Development and validation of a novel cerebral oximeter using near-infrared spectroscopy

作　　者：蔡世杰 李翰林 沈昭 于辉 叶继伦 张旭 CAI Shijie;LI Hanin;SHEN Zhao;YU Hui;YE Jiun;ZHANG Xu(Shenzhen Key Laboratory for Biomedical Engineering,Shenzhen 518060,China;School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen 518060,China;Guangdong Biolight Meditech Research Institute Co.,Ltd.,Zhuhai 519080,China)

机构地区：[1]深圳市生物医学工程重点实验室,广东深圳518060 [2]深圳大学医学部生物医学工程学院,广东深圳518060 [3]广东宝莱特医疗技术研究院有限公司,广东珠海519080

出　　处：《中国医学物理学杂志》2024年第7期876-882,共7页Chinese Journal of Medical Physics

基　　金：珠海市人才项目(2120004000207);深圳市科创委关键技术研发项目(JSGG20210713091811038)。

摘　　要：结合修正Lambert-Beer定律和空间分辨光谱技术,提出一种基于三波长的脑组织氧饱和度监测系统。搭建脑组织氧饱和度(rSO_(2))测量平台,从光谱稳定性和本底噪声验证系统可靠性,建立受控低氧试验并招募18名志愿者,研究rSO_(2)随吸入氧阶梯平台变化的趋势以及rSO_(2)与动脉血氧饱和度之间的关系。结果表明,该测量系统可以有效监测rSO_(2),测试结果符合测量要求。受控低氧序列中,随吸入氧浓度下降,rSO_(2)均呈下降趋势,且个体rSO_(2)与动脉血氧饱和度具有较高的相关性。A cerebral oximeter based on 3-wavelength spatially resolved spectroscopy and the modified Lambert-Beer law is proposed.A platform for monitoring the regional cerebral oxygen saturation(rSO_(2))is established,and the system reliability is verified through spectral stability and background noise test.Eighteen volunteers are recruited to participate in the controlled hypoxia test for exploring the trend of rSO_(2) with the sequence of stepped hypoxia platform and discussing the relationship between rSO_(2) and arterial blood oxygen saturation.The results show that the established system can effectively monitor rSO_(2) and meet the measurement requirements.During the controlled hypoxia sequence,as the fraction of inspired oxygen decreases,rSO_(2) shows a downward trend,and the individual rSO_(2) has a high correlation with arterial blood oxygen saturation.

关 键 词：脑组织氧饱和度 动脉血氧饱和度 近红外光谱 空间分辨光谱法 受控低氧实验 

分 类 号：R318[医药卫生—生物医学工程]