三七总皂苷预防血栓的机制  

Mechanism of Panax notoginseng saponins in the prevention of thrombosis

作　　者：李佩娟 王春梅[2] 赵茜[1,3] LI Peijuan;WANG Chunmei;ZHAO Qian(General Practice Ward/International Medical Center Ward,General Practice Medical Center,West China Hospital,Sichuan University,Chengdu 610041;Department of Critical Care Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053;General Medicine Teaching and Research Department,General Practice Medical Center,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院全科医学中心全科(特需)病房,四川成都610041 [2]首都医科大学宣武医院重症医学科,北京100053 [3]四川大学华西医院全科医学中心全科医学教研室,四川成都610041

出　　处：《基础医学与临床》2024年第7期912-915,共4页Basic and Clinical Medicine

基　　金：首都卫生发展科研专项(首发2022-2-2016)。

摘　　要：三七总皂苷(PNSs)作为三七的有效提取成分,用于预防血栓历史悠久。PNSs下调炎性因子表达,促进血管内皮细胞生长,上调抗凝物质和舒张血管分子表达,调节内皮细胞功能;PNSs多靶点抑制血小板黏附、释放和聚集;PNSs通过调节组织型纤溶酶原激活物和抑制物动态平衡,维持纤维蛋白溶解系统活性;PNSs降低血液黏度,改善红细胞指标,多途径抑制血栓形成。Panax notoginseng saponins(PNSs)as the extracted bioactive components of Panax notoginseng,have a long history of application in prevention of thrombosis.PNSs down⁃regulate the expression of inflammatory factors,promoting endothelial cell growth,up⁃regulating the expression of anticoagulants and vasodilators,and regulating endothelial cell function;With multiple targets at which PNSs inhibit platelet adhesion,release,and aggregation;PNSs maintain the activity of the fibrinolytic system by regulating the dynamic balance of tissue type plasminogen activators and inhibitors;PNSs reduce blood viscosity,improve red blood cell indicators,and inhibit thrombosis through multiple pathways.

关 键 词：三七总皂苷 血栓 机制 

分 类 号：R654.3[医药卫生—外科学]