新确诊糖尿病患者增加运动与降低胰岛素抵抗和心血管危险因素相关  

Increased exercise is associated with reduced insulin resistance and cardiovascular risk factors in individuals with newly diagnosed diabetes

作　　者：齐梦亚 李玉秀 余洁 张化冰 许翎岭 李伟 平凡 QI Mengya;LI Yuxiu;YU Jie;ZHANG Huabing;XU Lingling;LI Wei;PING Fan(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《基础医学与临床》2024年第7期984-988,共5页Basic and Clinical Medicine

基　　金：中国医学科学院医学与健康科技创新工程(2021-1-I2M-002)。

摘　　要：目的了解不同糖代谢受试者体力活动水平与胰岛素抵抗和心血管危险因素之间的关系,为不同糖代谢状态的人群运动干预提供依据。方法收集2017年至2021年北京市昌平区农村社区的691名成年受试者作为研究对象,用Spearman相关性分析研究不同糖代谢状态人群锻炼频率与胰岛素抵抗、胰岛素敏感性、颈围(NC)和颈围身高比(NHtR)之间的关系以及不同糖代谢组NC与胰岛素抵抗和胰岛素敏感性之间的关系。结果新确诊糖尿病组有171例(62.9%)受试者每天锻炼,占比最高。Spearman相关性分析展示了糖尿病组锻炼频率与三酰甘油-葡萄糖(TyG)指数(r=-0.120,P<0.05)和NC(r=-0.168,P<0.05)成负相关。在新确诊糖尿病组NC与三酰甘油(TG)(r=-0.100,P<0.05)、胰岛素抵抗指数(HOMA-IR)(r=-0.163,P<0.05)、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)(r=-0.214,P<0.05)、TyG指数(r=-0.156,P<0.05)成正比。结论运动频率的增加与新确诊糖尿病患者NC的减小、胰岛素抵抗和心血管危险因素的改善相关,运动对糖耐量正常和糖尿病前期的受试者的胰岛素抵抗的影响甚微,无统计学意义。Objective To identify the relationship between physical activity,insulin resistance and cardiovascular risk in individuals with different glucose tolerance status and to provide evidence for exercise intervention in people with different glucose tolerance status.Methods A total of 691 patients with different glucose metabolism status were recruited as subjects of the research.Spearman correlation analysis was used to study the relationship between exercise frequency and insulin resistance,insulin sensitivity,neck circumference(NC)and neck circumference height ratio(NHtR)in the subjects with different glucose metabolism status,the relationship between NC and insu⁃lin resistance and insulin sensitivity in different glucose metabolism groups.Results 171(62.9%)Subjects with diabetes were intervened by exercised every day.Spearman correlation analysis showed the correlation between exer⁃cise frequency and tri⁃glyceride triglyceride⁃glucose index(TyG index)(r=-0.120,P<0.05)and NC(r=-0.168,P<0.05)were negatively correlated.In subjects with diabetes,NC was positively correlated with triglyc⁃erides(TG)(r=-0.100,P<0.05),homeostasis model assessment of insulin resistance(HOMA⁃R)(r=-0.163,P<0.05),total cholesterol/high⁃density lipoprotein(TC/HDL⁃C)(r=-0.214,P<0.05)and TyG index(r=-0.156,P<0.05).Conclusions Increased frequency of exercise is associated with reduced NC,improved insulin resistance,and cardiovascular risk factors in subjects of our team with newly diagnosed diabetes.Exercise has no significant effect on insulin resistance of subjects with normal glucose tolerance and pre⁃diabetes.

关 键 词：运动 糖尿病 糖耐量异常 胰岛素抵抗 颈围 

分 类 号：R587.1[医药卫生—内分泌]