前列腺素E2在骨形成中的作用机制  

Mechanism of prostaglandin E2 in bone formation

作　　者：周若彤 庞倩倩 夏维波 ZHOU Ruo-tong;PANG Qian-qian;XIA Wei-bo(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院内分泌科,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第3期295-302,共8页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2021YFC2501704);国家自然科学基金(82270938,82200993);中央高水平医院临床科研业务费资助项目(2022-PUMCH-D-006,2022-PUMCH-B-014)。

摘　　要：前列腺素E2(prostaglandin E2,PGE2)作为体内一种重要的生物活性物质,通过作用于前列腺素E受体(prostaglandin E receptor,EP),参与内环境稳态的维持。PGE2在骨代谢调控中发挥重要作用,在骨重建的过程中,调控成骨细胞介导的骨形成与破骨细胞介导的骨吸收,维持动态平衡。在骨形成方面,PGE2/EP轴通过神经调控、机械负荷调控、与体内其他细胞分子间的交互作用,促进成骨细胞增殖分化,维持骨稳态。因此,PGE2在以骨量异常为特征的疾病中发挥关键作用,可能是潜在的治疗靶点。本文对近年来PGE2在骨形成中的调控机制进行综述,并总结现有的临床应用。Prostaglandin E2(PGE2),as an important bioactive substance in vivo,participates in the homeostasis maintenance by acting on the prostaglandin E receptor(EP)and plays an important role in the regulation of bone metabolism.In the process of bone remodeling,PGE2 maintains the balance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts.In bone formation,the PGE2/EP axis promotes osteoblast proliferation and differentiation and maintains bone homeostasis through neural modulation,mechanical loading,and interactions with other cellular molecules.Therefore,PGE2 plays a pivotal role in diseases characterized by abnormal bone mass,which means it maybe serve as the potential therapeutic target.This review summarized the regulatory mechanisms of PGE2 in bone formation and its clinical applications.

关 键 词：前列腺素E2 骨形成 神经调控 机械负荷 成骨细胞 

分 类 号：R589.9[医药卫生—内分泌]