多孔中药固体片剂孔隙率的太赫兹有效介质模型研究  

Terahertz study on the porosity of porous traditional Chinese medicine tablets by effective medium models

作　　者：李旭 张梦圆 赵雯玥 左剑[1] 朱卫丰 李哲 施宇蕾[1] 张存林[1] LI Xu;ZHANG Meng-Yuan;ZHAO Wen-Yue;ZUO Jian;ZHU Wei-Feng;LI Zhe;SHI Yu-Lei;ZHANG Cun-Lin(Key Laboratory of Terahertz Optoelectronics,Ministry of Education,Department of Physics,Capital Normal University,Beijing 100048,China;Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]首都师范大学物理系太赫兹光电子学教育部重点实验室,北京100048 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《红外与毫米波学报》2024年第3期344-353,共10页Journal of Infrared and Millimeter Waves

基　　金：国家自然科学基金(11204190,82003953,12174272)。

摘　　要：目前对中药片剂的孔隙测量,一般采用的是具有破坏性的密度测量方法,缺乏无损量化方法。太赫兹辐射能用于无损的提取药物若干光学信息。针对直压型中药片剂,通过太赫兹时域和频域信号处理等不同方法分别计算各种片剂的有效折射率,发现两种方法得到的有效折射率和片剂的孔隙率均呈良好的线性关系。根据有效折射率特性,利用四种有效介质模型提取了中药片剂的孔隙率并进行量化回归,通过交叉验证与相对分析误差(RPD)发现通过时域信号处理的有效折射率得到的孔隙率回归模型解释性与验证准确性更高,其中最佳模型是Bruggeman模型(RPD=11.3325)。为中药多孔粉体制剂工艺优化提供支持。Generally,the porosity of traditional Chinese medicine is measured by the destructive method of density measurement,but there is a lack of non-destructive quantification methods.As one important non-destructive method,terahertz radiation has been used to non-destructively extract the drugs'time-domain and frequency-domain optical information.For direct compression traditional Chinese medicine tablets,the effective refractive index of various tablets was obtained by different methods of terahertz time-domain signal processing and frequency-domain signal processing.It was found that the effective refractive indices with either signal processing method show a good linear relationship with the porosities of the tablets.The porosity of Puerariae Lobatae Radix tablets was extracted and modeled by linear regression based on four effective medium theory models.The porosity regression model based on the effective refractive index by time-domain signal processing shows better performance on the model interpretation and cross-validation accuracy,with the best model of the Bruggeman model(RPD=11.3325).It provides support for the process optimization of porous powder preparation of traditional Chinese medicine.

关 键 词：太赫兹光谱 有效折射率 有效介质理论 中药片剂孔隙率 

分 类 号：O433[机械工程—光学工程]