The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES)framework  

作　　者：Jakub Vohryzek Joana Cabral Christopher Timmermann Selen Atasoy Leor Roseman David J.Nutt Robin L.Carhart-Harris Gustavo Deco Morten L.Kringelbach 

机构地区：[1]Centre for Eudaimonia and Human Flourishing,Linacre College,Department of Psychiatry,University of Oxford,Oxford OX39BX,UK [2]Department of Psychiatry,University of Oxford,Oxford OX37JX,UK [3]Center for Music in the Brain,Aarhus University,Aarhus 8000,Denmark [4]Center for Brain and Cognition,Computational Neuroscience Group,Department of Information and Communication Technologies,Universitat Pompeu Fabra,Barcelona 08005,Spain [5]Life and Health Sciences Research Institute,School of Medicine,University of Minho,Braga 4710-057,Portugal [6]ICVS/3B’s-PT Government Associate Laboratory,Braga/Guimaraes 4710-057,Portugal [7]Centre for Psychedelic Research,Department of Brain Sciences,Imperial College London,London SW72AZ,UK [8]Departments of Neurology and Psychiatry,University of California San Francisco,San Francisco 94143,USA [9]Institucio Catalana de la Recerca i Estudis Avancats(ICREA),Barcelona 08010,Spain [10]Department of Neuropsychology,Max Planck Institute for Human Cognitive and Brain Sciences,Leipzig,Germany [11]School of Psychological Sciences,Monash University,Melbourne,Australia

出　　处：《National Science Review》2024年第5期39-48,共10页国家科学评论（英文版）

基　　金：supported by EUH2020FET Proactive project Neurotwin(101017716);supported by the European Research Council Consolidator Grant:CAREGIVING(615539);Pettit Foundation,Carlsberg Foundation,Center for Music in the Brain;the Danish National Research Foundation(DNRF117);supported by‘la Caixa’Foundation,Spain(LCF/BQ/PR22/11920014);the Portuguese Foundation for Science and Technology,Portugal(UIDB/50026/2020 andUIDP/50026/2020);supported by the Spanish Research Project(PSI2016-75688-P,Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional,European Union);the EuropeanUnion’s Horizon 2020 Research and Innovation Programme(720270(Human Brain Project[HBP]SGA1);785907(HBP SGA2));the Catalan Agency for Management of University and Research Grants(2017 SGR 1545).

摘　　要：The human brain is a complex system,whose activity exhibits flexible and continuous reorganization across space and time.The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions.However,the way these activity patterns are expressed over time with their changes in various brain states remains unclear.Here,we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT)with the Harmonic Decomposition of Spacetime(HADES)framework that can characterize how different harmonic modes defined in space are expressed over time.HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state.When normalizing the contributions by condition(DMT and non-DMT),we detect a decrease specifically in the second functional harmonic,which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics.Moreover,HADES’dynamic spacetime measures of fractional occupancy,life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关 键 词：spatio-temporal brain dynamics DMT harmonic modes 

分 类 号：O641.3[理学—物理化学] TB383.1[理学—化学]