Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices  

作　　者：Yuanyuan Li Zhipeng Chen Yuxin Liu Zijian Liu Tong Wu Yuanxi Zhang Lelun Peng Xinshuo Huang Shuang Huang Xudong Lin Xi Xie Lelun Jiang 

机构地区：[1]Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument,School of Biomedical Engineering,Shenzhen Campus of Sun Yat-Sen University,Shenzhen 518107,China [2]School of Mechanical and Electrical Engineering,Guangzhou University,Guangzhou 510006,China [3]State Key Laboratory of Optoelectronic Materials and Technologies,Guangdong Province Key Laboratory of Display Material and Technology,School of Electronics and Information Technology,Sun Yat-Sen University,Guangzhou 510006,China

出　　处：《National Science Review》2024年第5期265-283,共19页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation ofChina(T2225010,51975597 and 32171399);financial support from the Shenzhen Science and Technology Project(JCYJ20220818102201003 and JCYJ20220818100001002);the Shenzhen Sustainable Development Special Project(KCXFZ20230731094500001);the Natural Science Foundation of Guangdong Province(2022B1515020011);financial support from the National Key R&D Program of China(2021YFF1200700 and 2021YFA0911100);Fundamental Research Funds for the Central Universities(Sun Yat-sen University 22dfx02);the Independent Fund of the State Key Laboratory of Optoelectronic Materials and Technologies(Sun Yat-sen University,OEMT-2022-ZRC-04).

摘　　要：The limited lifespan of batteries is a challenge in the application of implantable electronic devices.Existing wireless power technologies such as ultrasound,near-infrared light and magnetic fields cannot charge devices implanted in deep tissues,resulting in energy attenuation through tissues and thermal generation.Herein,an ultra-low frequency magnetic energy focusing(ULFMEF)methodology was developed for the highly effective wireless powering of deep-tissue implantable devices.A portable transmitter was used to output the low-frequency magnetic field(<50 Hz),which remotely drives the synchronous rotation of a magnetic core integrated within the pellet-like implantable device,generating an internal rotating magnetic field to induce wireless electricity on the coupled coils of the device.The ULFMEF can achieve energy transfer across thick tissues(up to 20 cm)with excellent transferred power(4–15 mW)and non-heat effects in tissues,which is remarkably superior to existing wireless powering technologies.The ULFMEF is demonstrated to wirelessly power implantable micro-LED devices for optogenetic neuromodulation,and wirelessly charged an implantable battery for programmable electrical stimulation on the sciatic nerve.It also bypassed thick and tough protective shells to power the implanted devices.The ULFMEF thus offers a highly advanced methodology for the generation of wireless powered biodevices.

关 键 词：ultra-low frequency transcutaneous energy transmission electromagnetic generator implantable electronic device deep tissue 

分 类 号：TH-39[机械工程]