Unveiling the next generation of MRI contrast agents: current insights and perspectives on ferumoxytol-enhanced MRI  

作　　者：Guangxiang Si Yue Du Peng Tang Gao Ma Zhaochen Jia Xiaoyue Zhou Dan Mu Yan Shen Yi Lu Yu Mao Chuan Chen Yan Li Ning Gu 

机构地区：[1]Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,China [2]Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics,School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing 210029,China [3]Department of Radiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China [4]MR Collaboration,Siemens Healthineers Ltd.,Shanghai 200126,China [5]Department of Radiology,Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China [6]School of Mathematical Sciences,Capital Normal University,Beijing 100048,China [7]Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine,Institute of Clinical Medicine,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210093,China

出　　处：《National Science Review》2024年第5期378-397,共20页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(51832001,61821002 and 62394312);the Natural Science Foundation of Jiangsu Province(BK20222002);the Nanjing Science and Technology Development Foundation(202205066).

摘　　要：Contrast-enhanced magnetic resonance imaging(CE-MRI)is a pivotal tool for global disease diagnosis and management.Since its clinical availability in 2009,the off-label use of ferumoxytol for ferumoxytol-enhanced MRI(FE-MRI)has significantly reshaped CE-MRI practices.Unlike MRI that is enhanced by gadolinium-based contrast agents,FE-MRI offers advantages such as reduced contrast agent dosage,extended imaging windows,no nephrotoxicity,higherMRI time efficiency and the capability for molecular imaging.As a leading superparamagnetic iron oxide contrast agent,ferumoxytol is heralded as the next generation of contrast agents.This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI,providing an avant-garde medical-engineering interdisciplinary lens,thus bridging the gap between clinical demands and engineering innovations.Concurrently,we spotlight the emerging imaging themes and new technical breakthroughs.Lastly,we share our own insights on the potential trajectory of FE-MRI,shedding light on its future within the medical imaging realm.

关 键 词：FERUMOXYTOL contrast agent contrast-enhancedMRI ferumoxytol-enhancedMRI 

分 类 号：R563[医药卫生—呼吸系统] TP212.3[医药卫生—内科学]