头孢卡品体外抗菌作用研究  

Study on in vitro activity of cefcapene

作　　者：李耘[1] 薛峰[1] 刘姚姚 郑波[1] LI Yun;XUE Feng;LIU Yao-yao;ZHENG Bo(Institute of Clinical Pharmacology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院临床药理研究所,北京100034

出　　处：《中国临床药理学杂志》2024年第12期1728-1733,共6页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价头孢卡品对近3年临床常见分离菌的体外抗菌活性。方法收集临床分离细菌,采用标准微量肉汤二倍稀释法测定头孢卡品的最低抑菌浓度(MIC)。结果对2021—2023年全国范围内临床分离的308株细菌进行了MIC测定。头孢卡品对链球菌属及甲氧西林敏感金黄色葡萄球菌(MSSA)具有较好抗菌作用,与青霉素、头孢泊肟相似,优于头孢呋辛、头孢克洛和头孢克肟。在革兰氏阴性菌中,头孢卡品对非产超广谱β内酰胺酶(ESBLs)大肠埃希菌及流感嗜血杆菌、卡他莫拉菌具有较好抗菌活性,与头孢克肟、头孢泊肟相似,优于头孢呋辛和头孢克洛。结论头孢卡品对国内近年临床分离社区获得性肺炎等感染常见致病菌,包括肺炎链球菌、MSSA、流感嗜血杆菌、卡他莫拉菌等均有很好抗菌作用,与国内10年前及国外报道相似,为适合成人及儿童呼吸道感染、中耳炎、鼻窦炎、尿路感染等门诊感染的高效口服头孢菌素。Objective To evalucate in vitro activity of cefcapene against clinical isolated pathogenic bacteria in recent three years in China.Methods The clinical isolates were collected and the minimal inhibitory concentrations(MICs)were determined by the microbroth dilution method.Results A total of 308 pathogenic bacteria over the period 2021-2023 were studied.Cefcapene exhibited excellent antibacterial activity against Streptococci and methicillin susceptible Staphylococcus aureus(MSSA),which was similar to penicillin and cefpodoxime,and better than cefuroxime,cefaclor and cefixime.Against gram-negative bacteria,cefcapene also showed better antibacterial activity,especially against non-extended spectrumβ-lactamases(ESBLs)Escherichia coli,Haemophilus influenzae and Moraxella catarrhalis,were comparable to cefixime and cefpodoxime,better than cefuroxime and cefaclor.Conclusion Cefcapene showed excellent antibacterial activity against clinical isolates from community-acquired pneumonia,include streptococcus pneumonia,MSSA,Haemophilus influenzae and Moraxella catarrhalis in recent years in China,which identical with those reported in literature ten years ago in China and foreign.It is a highly effective oral cephalosporin suitable for adults and children with respiratory tract infection,otitis media,sinusitis,urinary tract infection and other outpatient infections.

关 键 词：头孢卡品 体外 最低抑菌浓度 口服头孢菌素 

分 类 号：R978.1[医药卫生—药品]