整合药理学在中医药现代研究的若干进展  

Integrated Pharmacology of Traditional Chinese Medicine:A Review

作　　者：李珊珊 李玮婕 王萍 LI Shanshan;LI Weijie;WANG Ping(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2024年第14期270-278,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中国中医科学院科技创新工程项目(CI2021A04904,CI2021A04907);中药研究所中药药理学创新团队项目(CI2021B015);国家重点研发计划“政府间国际科技创新合作重点专项”(2022YFE0119300)。

摘　　要：中药方剂作为临床治疗的主要形式和手段,是中医理法方药的关键环节,是中医学理论和临床实践的桥梁,探索中药方剂的化学物质实体和机体生命活动的关系及其复杂交互规律,是中药现代研究的关键科学问题之一。然因本身组成的复杂性、生物效应表达的多样性,使其“化学成分群-体内过程-药效活性”之间缺乏“完整的证据链”,存在严重的“碎片化”现象。整合药理学的提出,是中药复杂系统分子作用解析的有效策略和方法,特别体现了以生物技术革命为代表的第四次浪潮的时代背景下,利用互联网、大数据、人工智能为代表的新技术驱动中药复杂体系发展的新趋势,为系统揭示多成分药物与机体相互作用及其整合规律和作用原理提供了一条切实可行的途径。该文试从中药整合药理学的形成和发展、研究思路、关键技术及应用等方面进行综述,为阐释中医药理论的科学内涵和中医原创思维的科学价值、总结与传承名医经验、中药质量控制、中药作用原理阐释和中药新药研发等提供强有力支持。Chinese medicinal formulae(CMF),as the main form and means of clinical treatment,are a key link in traditional Chinese medicine(TCM)theory and clinical practice.Exploring the relationship between the chemical substances of CMF and the life activities of the body,as well as their complex interaction patterns,is one of the key issues in modern research of TCM.However,due to the complexity of chemical composition and the diversity of biological effects,evidence remains to be mined for the chain involving chemical composition,in vivo process,and pharmacological activity of CMF,which results in serious fragmentation of related studies.Integrated pharmacology is proposed as an effective strategy for analyzing the molecular interactions of complex systems in TCM.Particularly,it reflects the new trend of using new technologies such as the Internet,big data,and artificial intelligence to drive the development of complex systems in TCM in the context of the fourth wave represented by the biotechnology revolution.This provides a practical and feasible approach for systematically revealing the interaction,integration patterns,and principles of action between multi-component drugs and the body.This article reviews the emergence and development,research ideas,key technologies,and applications of integrated pharmacology of TCM,providing support for explaining the scientific connotation of TCM theory and the scientific value of original thinking of TCM,inheriting the experience of famous doctors,and facilitating the quality control,mechanism explanation,and new medicine development of TCM.

关 键 词：整合药理学 中药方剂 证候生物内涵 安全性和有效性 质量控制 药效物质基础 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33