胰肾联合移植受者新型冠状病毒感染继发肺毛霉菌病1例  

COVID-19 infection secondary to pulmonary mucormycosis in a recipient of simultaneous pancreas-kidney transplantation:one case report

作　　者：陈荣鑫[1] 方佳丽[1] 李光辉[1] 刘路浩[1] 吴佳林[1] 郭泽彬 陈正[1] Chen Rongxin;Fang Jiali;Li Guanghui;Liu Luhao;Wu Jialing;Guo Zebin;Chen Zheng(Department of Organ Transplantation,Second Affiliated Hospital,Guangzhou Medical University,Guangzhou 510260,China;Department of Intensive Care Unit,Second Affiliated Hospital,Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院器官移植科,广州510260 [2]广州医科大学附属第二医院重症医学科,广州510260

出　　处：《中华器官移植杂志》2024年第6期408-411,共4页Chinese Journal of Organ Transplantation

基　　金：广东省医学科学技术研究基金项目(A2022250);广州市泌尿疾病学重点学科(2021-2023);广州医科大学临床重点专科(010004001);广州市临床重大科技项目(2019ZD12)。

摘　　要：回顾1例新型冠状病毒感染继发肺毛霉菌病胰肾联合移植受者的诊疗经过。该例早期运用宏基因二代测序技术明确病原体,在根据病情及肝功能变化先后针对性的予以两性霉素B脂质体静脉滴注、两性霉素B雾化及漱口以及序贯维持口服泊沙康唑后,受者肺部感染病灶吸收,移植胰腺功能稳定,肌酐、尿素较感染前下降,取得了较好的疗效。One case of COVID-19 infection secondary to pulmonary mucormycosis in a recipient of simultaneous pancreas-kidney transplantation was described.Early identification of the pathogen was achieved by metagenomic next-generation sequencing.On the basis of disease status and liver function changes,targeted treatments included intravenous amphotericin B liposome,amphotericin B nebulization&gargling and subsequently a maintenance therapy of oral posaconazole.This regimen resulted in the absorption of lung infection,stabilization of transplanted pancreas function and reduced levels of creatinine and urea as compared to pre-infection period.The therapeutic efficacy was decent.

关 键 词：胰肾联合移植 肺毛霉病 新型冠状病毒感染 

分 类 号：R699.2[医药卫生—泌尿科学] R657.5[医药卫生—外科学] R511[医药卫生—临床医学]