冠心病合并肺部感染患者IL-15和PCT及凝血纤溶因子表达水平变化与相关危险因素  

IL-15,PCT and coagulation fibrinolysin expression and related risk factors in patients with coronary heart disease combined with pulmonary infection

作　　者：吴婷婷 钱涛 李涛[1] 李伟[1] 杨丽婷 WU Tingting;QIAN Tao;LI Tao;LI Wei;YANG Liting(Department of Cardiology,Shuyang County Hospital of Traditional Chinese Medicine,Shuyang,Jiangsu 223600,China;Department of Infection,Shuyang County Hospital of Traditional Chinese Medicine,Shuyang,Jiangsu 223600,China)

机构地区：[1]沭阳县中医院心内科,江苏沭阳223600 [2]沭阳县中医院感染科,江苏沭阳223600

出　　处：《热带医学杂志》2024年第5期694-697,共4页Journal of Tropical Medicine

基　　金：江苏省中西医结合老年病防治重点实验室开放课题(202231)。

摘　　要：目的探讨冠心病合并肺部感染患者血清白细胞介素15(IL-15)、降钙素原(PCT)及凝血纤溶因子表达水平变化,分析肺部感染相关危险因素。方法选择2021年1月-2022年12月沭阳县中医院接诊的100例冠心病患者为研究对象,根据感染发生情况分为感染组(n=24)和对照组(n=76),分析血清IL-15、PCT及凝血纤溶因子水平变化情况与相关危险因素。结果两组性别、饮酒、糖尿病、高血压、冠心病家族史、氨基末端脑钠肽前体(NTproBNP)及D-二聚体水平比较差异均无统计学意义(P均>0.05),感染组平均年龄、吸烟率、住院时间、呼吸机治疗率均高于对照组,差异均有统计学意义(t/χ^(2)=4.459、7.888、9.639、6.836,P均<0.05)。感染组患者血清IL-15、PCT、凝血酶时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及组织纤溶酶原抑制物(PAI)水平显著高于对照组,纤溶酶原(PLG)水平显著低于对照组,差异均有统计学意义(t=19.028、8.813、9.647、4.487、5.124、5.404、4.204,P均<0.05);预后不良患者血清IL-15、PCT、PT、APTT、FIB及PAI水平显著高于预后良好患者,PLG水平显著低于预后良好患者,差异均有统计学意义(t=12.463、3.149、8.938、2.467、8.004、11.634、7.093,P均<0.05)。多因素非条件logistic分析显示,年龄、吸烟、住院时间、呼吸机治疗、血清IL-15、PCT、PT、APTT、FIB、PLG及PAI水平均是冠心病并发肺部感染的独立危险因素(P均<0.05)。结论在冠心病合并肺部感染患者中IL-15、PCT及凝血纤溶因子表达异常,且危险因素较多,临床应重点关注导致其发生的独立危险因素。Objective To investigate the expression of interleukin-15(IL-15), procalcitonin(PCT) and coagulation fibrinolysin and related risk factors in patients with coronary heart disease complicated with pulmonary infection. Methods A total of 100 patients with coronary heart disease admitted to Shuyang County Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected as subjects of this study. According to the incidence of infection, they were divided into infection group(n=24), and patients without infection were selected as control group(n=76). The changes of serum IL-15, PCT and coagulation fibrinolysin levels and related risk factors were analyzed. Results There were no significant differences in gender, alcohol consumption, diabetes, hypertension, family history of coronary heart disease,N terminal pro B type natriuretic peptide(NT-proBNP) and D-dimer levels between the two groups(all P>0.05).Age, smoking, length of hospital stay and ventilator treatment in the infected group were higher than those in the control group;the differences were statistically significant(t/χ^(2)=4.459, 7.888, 9.639, 6.836;all P<0.05). Serum levels of IL-15, PCT, phrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB) and plasminogenemia activator inhibitor(PAI) in the infected group were significantly higher than those in the control group, level of profibrinolysin(PLG) was significantly lower than that in the control group;the differences were statistically significant(t=19.028, 8.813, 9.647, 4.487, 5.124, 5.404, 4.204;all P<0.05). Serum levels of IL-15, PCT, PT, APTT, FIB and PAI were significantly higher in patients with poor prognosis than those in the patients with good prognosis;PLG level was significantly lower than that of patients with good prognosis, and the differences were statistically significant(t=12.463, 3.149, 8.938, 2.467, 8.004, 11.634, 7.093;all P<0.05). Multivariate logistic analysis showed that age, smoking, length of hospital stay, ventilator treatment, serum

关 键 词：肺部感染 冠心病 白细胞介素15 降钙素原 凝血纤溶因子 

分 类 号：R541.4[医药卫生—心血管疾病]