雷公藤多苷对慢性肾功能衰竭腹膜透析患者感染风险的影响  

Effects of tripterygium glycosides on infection risk in patients with CRF undergoing PD

作　　者：李攀[1] 刘新宇[2] 李海剑[3] LI Pan;LIU Xinyu;LI Haijian(Department of Nephrology,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Blood Purification,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Rheumatology and Immunology,Nanyang Central Hospital,Nanyang,Henan 473000,China)

机构地区：[1]南阳市中心医院肾脏内科,河南南阳473000 [2]南阳市中心医院血液净化科,河南南阳473000 [3]南阳市中心医院风湿免疫科,河南南阳473000

出　　处：《热带医学杂志》2024年第5期704-707,720,共5页Journal of Tropical Medicine

基　　金：河南省科技发展计划项目(212102310811)。

摘　　要：目的分析雷公藤多苷对慢性肾功能衰竭(CRF)腹膜透析(PD)患者感染风险的影响,为临床治疗提供依据。方法选取2020年1月-2022年6月南阳市中心医院196例CRF患者,随机数字表法分为两组,各98例。对照组予以PD治疗,观察组在对照组基础上联合雷公藤多苷治疗。比较两组疗效、感染风险、治疗前后肾功能、免疫功能及微炎症状态。结果观察组总有效率为90.82%(89/98),高于对照组的80.61%(79/98),差异有统计学意义(χ^(2)=4.167,P<0.05)。观察组腹膜透析相关性腹膜炎(PDRP)为1.02%(1/98),低于对照组的7.14%(7/98),差异有统计学意义(χ^(2)=4.691,P<0.05)。治疗后,观察组尿素氮(BUN)、24小时尿蛋白定量(UTP)、肌酐(Scr)低于对照组,差异有统计学意义(t=10.823、13.019、8.899,P均<0.05);治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(t=7.171、7.504、4.665,P均<0.05)。治疗后,观察组血清白细胞介素(IL)-8、IL-6、肿瘤坏死因子-α低于对照组,差异有统计学意义(t=14.259、24.666、17.725,P均<0.05)。结论雷公藤多苷对CRF进行PD治疗患者的疗效确切,能减少患者感染风险,改善肾功,促进免疫功能恢复,缓解微炎症状态。Objective To analyzed the effects of tripterygium glycosides on infection risk in patients with chronic renal failure(CRF) undergoing peritoneal dialysis(PD), provided the basis for clinical treatment. Methods A total of 196patients with CRF in the Nanyang Central Hospital were enrolled and randomly divided into control group(PD) and observation group(tripterygium glycosides combined with PD) between January 2020 and June 2022, 98 cases in each group. The curative effect, infection risk, renal function, immunity and microinflammation state in the two groups were compared before and after treatment. Results The total response rate in observation group was higher than that in control group [90.82%(89/98) vs. 80.61%(79/98)], and incidence of peritoneal dialysis-related peritonitis(PDRP) was lower than that in control group [1.02%(1/98) vs. 7.14%(7/98)];the differences were statistically significant (χ^(2)=4.167, 4.691;all P<0.05). After treatment, levels of blood urea nitrogen(BUN), 24 h urinary protein(UTP) and creatinine(Scr) in observation group were lower than those in control group;the differences were statistically significant(t=10.823, 13.019, 8.899;all P<0.05). After treatment, CD3^(+), CD4^(+) and CD4^(+)/CD8^(+) in observation group were higher than those in control group, the differences were statistically significant(t=7.171, 7.504, 4.665;all P<0.05). After treatment, levels of serum interleukin(IL)-8, IL-6 and tumor necrosis factor-α in observation group were lower than those in control group;the differences were statistically significant(t=14.259, 24.666, 17.725;all P<0.05). Conclusion The curative effect of tripterygium glycosides was significant on PD patients with CRF, which could reduce infection risk, improve renal function, promote immunity recovery and alleviate microinflammation state.

关 键 词：慢性肾功能衰竭 雷公藤多苷 腹膜透析 感染风险 

分 类 号：R692.5[医药卫生—泌尿科学]