高血压家族史与高尿酸交互作用对代谢综合征患病的影响  

The impact of the interaction between family history of hypertension and high uric acid on the prevalence of metabolic syndrome

作　　者：吕雅莉 喜小梅 刘永斌 颉亚辉 吴建军 魏兴民 LYU Yali;XI Xiaomei;LIU Yongbin;XIE Yahui;WU Jianjun;WEI Xingmin(School of Public Health,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;Department of Cardiology,the Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730060,China)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]甘肃中医药大学第四附属医院心内科,甘肃兰州730060

出　　处：《热带医学杂志》2024年第5期753-758,共6页Journal of Tropical Medicine

基　　金：甘肃省教育厅科技创新基金项目(2022B-122);西北环境与营养相关疾病中医药防控协同创新中心2024年度开放基金(ZYXT-24-05);。

摘　　要：目的了解高血压家族史与高尿酸对代谢综合征(MS)患病的交互作用,为MS的防治提供参考依据。方法采用1∶2匹配的病例对照研究,选取2022年1-12月在甘肃中医药大学第四附属医院体检中心参加职业健康检查的某石化企业职工,通过体格检查和实验室检测等信息将诊断为MS的840例患者作为病例组,以同期参加健康检查且同性别、年龄(±3岁)的非MS者1680例作为对照组。采用SPSS 25.0软件进行χ^(2)检验、logistic回归分析;通过相乘和相加模型评价高血压家族史和高尿酸的交互作用对MS患病的影响。结果病例组和对照组在肥胖、高血压家族史、糖尿病家族史、高尿酸的情况差异均有统计学意义(χ^(2)=315.314、9.502、7.920、80.730,P均<0.05)。调整混杂因素后,多因素logistic回归分析结果表明,高血压家族史与MS无关,高尿酸(OR=2.059,95%CI:1.639~2.588)与MS患病的高风险相关,差异有统计学意义(P<0.05)。交互作用分析显示,高血压家族史与高尿酸对MS患病存在相乘交互作用(OR=2.129,95%CI:1.275~3.555,P<0.05);同时二者也存在相加交互作用,相加交互作用评价指标,如超额相对危险度(RERI)、交互作用归因比(AP)、交互作用指数(S)分别为1.407(95%CI:0.223~2.591)、0.381(95%CI:0.160~0.603)、2.102(95%CI:1.210~3.650)。结论高血压家族史与高尿酸对MS患病存在交互作用,两者同时存在增加MS的患病风险。Objective To understand the interaction between family history of hypertension and high uric acid on metabolic syndrome(MS), and provide reference for the prevention and treatment of MS. Methods Use 1∶2 matched case-control study, 840 patients diagnosed with MS were selected as a case group based on physical examination and laboratory testing information from employees of a petrochemical enterprise who participated in occupational health examination at the physical examination center of the Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine from January to December 2022. 1 680 non-metabolic syndrome people with the same sex and age (±3 years) who participated in the health examination during the same period were selected as the control group. The SPSS 25.0 software was used for χ^(2) test and logistic regression analysis. Multiplicative and additive models were used to evaluate the interaction of family history of hypertension and high uric acid on the incidence of MS. Results Obesity, family history of hypertension, family history of diabetes, and hyperuric acid between case group and control group showed statistically significant differences(χ^(2)=315.314,9.502,7.920,80.730;all P<0.05). After adjusting for confounding factors, multivariate logistic regression analysis showed that family history of hypertension was not associated with MS, high uric acid(OR=2.059,95%CI:1.639-2.588)were associated with the high risk of metabolic syndrome, the difference was statistical significance(P<0.05). Interaction analysis showed that family history of hypertension and high uric acid had a multiplicative interaction on the incidence of MS(OR=2.129,95%CI:1.275-3.555, P<0.05). At the same time, they also had additive interaction, and the evaluation indexes such as the relative excess risk due to interaction(RERI),the atributable proportion due to interaction(AR) and the synergy index(S) of additive interaction were 1.407(95%CI:0.223-2.591), 0.381(95%CI:0.160-0.603),2.102(95%CI:1.210-3.650). Conc

关 键 词：高血压家族史 高尿酸 代谢综合征 交互作用 

分 类 号：R589[医药卫生—内分泌]