纳米材料在皮肤结核病诊疗中的潜在应用  

Potential applications of nanomaterials in diagnosis and treatment of cutaneous tuberculosis

作　　者：林倩妃 范书豪 皮江 LIN Qian-fei;FAN Shu-hao;PI Jiang(College of Medical Technology,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东医科大学医学技术学院,广东东莞523808

出　　处：《广东医科大学学报》2024年第3期227-240,共14页Journal of Guangdong Medical University

基　　金：国家自然科学基金(82272348);广东省自然科学基金(2023A1515030195,2022A1515011223);广东医科大学学科建设类“临床+基础”专项项目(4SG24010G)。

摘　　要：皮肤结核病(CTB)是由结核分枝杆菌(Mtb)直接侵犯皮肤或由其他脏器结核灶内的Mtb扩散感染皮肤引起的传染病,严重威胁全球公共卫生安全。目前,传统皮肤结核病诊断与治疗方法存在误诊率高、毒副作用大、易产生耐药性、治疗效果欠佳以及缺乏针对性诊疗方案等问题,严重阻碍了CTB的有效控制和治疗。为克服这些难题,研发快速、精确的诊断技术以及安全、高效的治疗方案显得尤为迫切和重要。基于纳米材料的新型技术在医学领域呈现出巨大的潜力和广阔的应用前景。该文综述了基于纳米材料研发的新型检测技术以及新纳米药物所具有的特性在CTB诊断与治疗中的潜在应用。Cutaneous tuberculosis(CTB)is a contagious disease caused by Mycobacterium tuberculosis(Mtb)that invades the skin directly or spreads from tuberculosis foci in other organs,posing a serious threat to global public health security.Currently,traditional diagnostic and treatment strategies for CTB have some issues such as high misdiagnosis rates,significant side effects,susceptibility to drug resistance,suboptimal therapeutic outcomes,and lack of targeted diagnosis and treatment plans,which severely hinder the effective control and treatment of CTB.To overcome these challenges,the development of rapid and accurate diagnostic technologies,as well as safe and effective treatment strategies are particularly urgent and important.Novel technologies based on nanomaterials have shown tremendous potential and broad application prospects in medical fields.This article summarizes the potential applications of new detection technologies developed based on nanomaterials and the characteristics of novel nano-drugs in the diagnosis and treatment of CTB.

关 键 词：纳米材料 皮肤结核病 诊断 治疗 

分 类 号：TB383[一般工业技术—材料科学与工程] R529.4[医药卫生—内科学]