甘草素对肺动脉高压大鼠肺血管重塑及右心重构的影响  

Glycyrrhizin ameliorates right ventricular remodeling in pulmonary hypertension

作　　者：郑欢 郑珍珍 杨怡恬 张媛 陈鸣娣 姚卫民 成俊芬 陈日垦 ZHENG Huan;ZHENG Zhen-zhen;YANG Yi-tian;ZHANG Yuan;CHEN Ming-di;YAO Wei-min;CHENG Junfen;CHEN Ri-ken(Department of Endocrinology,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China;Department of Respiratory Medicine,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China;First school of clinical medicine,Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]广东医科大学附属第二医院内分泌科,广东湛江524003 [2]广东医科大学附属第二医院呼吸内科,广东湛江524003 [3]广东医科大学第一临床医学院,广东湛江524023

出　　处：《广东医科大学学报》2024年第3期251-254,共4页Journal of Guangdong Medical University

基　　金：广东省自然科学基金(2022A1515012375);广东省医学科研基金项目(A2024728,A2024723);湛江市科技发展专项基金竞争配置项目(2021A05086)。

摘　　要：目的探讨甘草素对肺动脉高压(PAH)大鼠肺血管重塑及右心重构的影响。方法采用腹腔注射野百合碱(MCT)诱导法建立PAH大鼠模型。MCT建模2周后分别给予60和20 mg/kg甘草素干预2周,观察大鼠右心室收缩压(RVSP)、右心室肥厚指数(RVHI)、大鼠肺动脉组织和右心室心肌组织HE染色结果,以及检测大鼠血浆环磷酸鸟苷(cGMP)和肺动脉组织蛋白激酶G(PKG)水平。结果60和20 mg/kg甘草素均能降低MCT诱导的PAH大鼠RVSP及RVHI,增加cGMP和PKG蛋白表达(P<0.01或0.05)。结论甘草素对PAH大鼠肺血管重塑及右心重构有一定的效果。Objective The aim of this study is to investigate the effect and the underlying mechanisms of glycyrrhizin on pulmonary vascular remodeling and right heart remodeling in rats with pulmonary arterial hypertension(PAH).Methods The PAH rat model was established by intraperitoneal injection of monocrotaline(MCT).After 2 weeks of MCT modeling,the rats were given 60 mg/kg and 20 mg/kg glycyrrhizin for 2 weeks.Right ventricular systolic pressure(RVSP),pulmonary vascular remodeling and right heart remodeling were observed.The plasma levels of cyclic guanosine phosphate(cGMP)and pulmonary tissue protein kinase G(PKG)were measured.Results The results showed that both 60 and 20 mg/kg glycyrrhizin decreased RVSP and RVHI in MCT-induced PAH rats,and increased the protein expression levels of cGMP and PKG(P<0.01 or 0.05).Conclusion Glycyrrhizin has certain effect on pulmonary vascular remodeling and right heart remodeling in PAH rats.

关 键 词：甘草素 肺动脉高压 右心重构 CGMP PKG 

分 类 号：R543.2[医药卫生—心血管疾病]