聚醚醚酮纤维负载氧化铋的压电效应对成骨细胞分化的刺激作用  

Piezoelectric Effect of Polyether Ether Ketone Fibers Loaded with Bismuth Oxide Stimulating Osteogenic Differentiation

作　　者：梁露娴 宋安琪 周扬 孙平 王德强[1] 魏杰[1] LIANG Luxian;SONG Anqi;ZHOU Yang;SUN Ping;WANG Deqiang;WEI Jie(Key Laboratory for Ultrafine Materials of the Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;Department of Orthopaedics,Shanghai Eighth People’s Hospital,Shanghai 200235,China)

机构地区：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237 [2]上海市第八人民医院骨科,上海200235

出　　处：《高等学校化学学报》2024年第7期173-182,共10页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:32171340)资助.

摘　　要：采用超声剥离法制备压电性能优良的氧空位氧化铋(BiO_(2-x)),利用绿原酸将BiO_(2-x)负载在聚醚醚酮(PEEK)纤维表面,制备了一种具有压电效应的肩袖补片材料,研究了该材料对巨噬细胞极化和成骨细胞分化行为的影响.结果表明,负载BiO_(2-x)后,PEEK纤维不仅表面性能(粗糙度、亲水性和表面能等)明显改善,而且压电性能也显著提高(压电系数为3.8pC/N,开路电压为0.97V,短路电流为575.6μA).该材料不仅促进巨噬细胞向抗炎型M2极化,而且促进成骨细胞黏附、增殖和成骨分化,在修复肩袖撕裂方面具有潜在的应用前景.Oxygen-vacancy bismuth oxide(BiO_(2-x))with excellent piezoelectric property was prepared by ultrasonic peel method and loaded on polyether ether ketone(PEEK)fiber by using chlorogenic acid.A kind of rotator cuff patch material with piezoelectric effect was designed,and its effects on macrophage polarization and osteoblast behavior were studied.The results showed that after loading BiO_(2-x),not only the surface properties(roughness,hydrophilicity,and surface energy,etc.)of PEEK fibers were obviously improved,but also the piezoelectric properties were significantly enhanced(piezoelectric coefficient of 3.8 pC/N,output voltage of 0.97 V and output current of 575.6μA).The patch material not only promoted the anti-inflammatory M2 macrophage polarization,but also promoted the adhesion,proliferation,and osteogenic differentiation of osteoblasts.The patch material has potential application for repairing rotator cuff tear.

关 键 词：聚醚醚酮纤维 表面改性 压电性能 巨噬细胞极化 成骨细胞分化 

分 类 号：O631[理学—高分子化学]