天然高分子基角膜修复材料力学性能研究进展  

Research progress on mechanical properties of natural polymer based corneal repair materials

作　　者：刘杨[1,2] 张传蕾 孔彦惠 刘慧玉 任天 刘潇 丁硕秋 LIU Yang;ZHANG Chuanlei;KONG Yanhui;LIU Huiyu;REN Tian;LIU Xiao;DING Shuoqiu(School of Medical and Health Engineering,Changzhou University,Changzhou 213164,China;School of Pharmacy,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学医学与健康工程学院,江苏常州213164 [2]常州大学药学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2024年第4期71-81,共11页Journal of Changzhou University：Natural Science Edition

基　　金：国家自然科学基金资助项目(81900814);江苏省科技厅自然科学基金面上资助项目(BK20171196);浙江省重点研发计划资助项目(2020C03003)。

摘　　要：由于盲人数量庞大、可供移植的捐赠角膜供不应求,人工角膜逐渐成为研究热点,但人工角膜常因力学性能不足而发生植片撕裂,为克服这一问题,国内外研究者开展了一系列研究工作尝试改善人工角膜的力学性能。文章针对胶原蛋白、明胶、丝素蛋白以及壳聚糖这4类常见的天然高分子基角膜修复材料的力学性能相关进展进行了总结。结果发现,通过光交联、热交联等物理方法,1-乙基-3-(3-二甲基氨基丙基)碳二亚胺(EDC)/N-羟基琥珀酰亚胺(NHS)交联、京尼平或戊二醛交联等化学方法以及其他复合方法都可以显著提升角膜材料的力学性能,但这些方法仍存在一些不足之处。因此,进一步开发高质量人工角膜至关重要,文章通过归纳总结希望能够为角膜修复材料的力学性能提升研究提供一些参考和思路。Due to the large number of blind individuals and the shortage of donor corneas available for transplantation,artificial corneas have gradually become a research hotspot.However,artificial corneas often experience implant tearing due to insufficient mechanical properties.In order to solve this problem,researchers at home and abroad have tried to improve the mechanical properties of corneal repair materials by a series of research work.This paper summarizes the progress relating to the mechanical properties of four common natural polymer-based corneal repair materials,namely collagen,gelatin,silk fibroin,and chitosan.The results show that physical methods such as photo-crosslinking and thermal crosslinking,chemical methods such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide(EDC)/N-hydroxysuccinimide(NHS)crosslinking,genipine or glutaraldehyde crosslinking and other composite methods can significantly improve the mechanical properties of corneal materials,but these methods still have some shortcomings.Therefore,further development of high-quality artificial corneas is crucial.It is hoped that the article can provide some reference and ideas for the study of improving the mechanical properties of corneal repair materials through summarization.

关 键 词：角膜修复 天然高分子材料 组织工程 人工角膜 力学性能 

分 类 号：R318.08[医药卫生—生物医学工程]