甲磺酸达氟沙星N-脱甲基杂质的合成研究  

Synthesis of N-Demethylated Impurities in Danofloxacin Mesylate

作　　者：单国洋 黄秋波 许培德 曹勇 凃鑫 SHAN Guo-yang;HUANG Qiu-bo;XU Pei-de;CAO Yong;TU Xin(Zhejiang Guobang Pharmaceutical Co.,Ltd.,Shangyu 312369,China)

机构地区：[1]浙江国邦药业有限公司,浙江上虞312369

出　　处：《精细化工中间体》2024年第3期52-54,共3页Fine Chemical Intermediates

摘　　要：研究一种制备甲磺酸达氟沙星N-脱甲基杂质标准品的方法。以甲磺酸达氟沙星为起始原料,通过碘氧化实现N-脱甲基反应,随后进行精制和后处理步骤,最终获得含量97.13%(HPLC)的目标杂质标准品N-脱甲基。方法操作简便且产物纯度高,其结构经^(1)H NMR、HRMS等确证。This research is to develop a method for preparing N-demethylated impurity reference standards of Dafloxacin Mesylate.This method uses Danofloxacin Mesylate as the initial raw material,it also utilized iodinemediated oxidation to carry out the demethylation reaction.Following this,refinement and post-processing steps are conducted to reach a target for impurity reference standards N-demethyl at 97.13%(HPLC).The advantages of this approach lie in its simplicity of operation and the high purity of the product,with the structure confirmed by techniques such as ^(1)H NMR and HRMS.

关 键 词：达氟沙星 N-脱甲基杂质 合成 

分 类 号：TQ465[化学工程—制药化工]