有机余辉材料的类别及其在生物分析成像中的研究进展  

Categories of Organic Afterglow Materials and Research Progress in Bioanalytical Imaging

作　　者：韩晨 孟红敏 李朝辉[1] HAN Chen;MENG Hongmin;LI Zhaohui(College of Chemistry,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学化学学院,郑州450001

出　　处：《集成技术》2024年第4期82-97,共16页Journal of Integration Technology

基　　金：国家自然科学基金面上项目(22374136,22274143)。

摘　　要：有机余辉材料是一类具有余辉特性的光学材料,可在光照结束后进行长时间发光,从而延长成像时间,并提高成像灵敏度。有机余辉材料凭借其灵活的可设计性与良好的生物相容性已被广泛应用于生物分析成像中。此外,余辉成像由于不需要实时激发光源,因而可有效消除生物组织自身荧光信号的干扰。因此,余辉成像在活体成像信背比和分析灵敏度方面具有明显的优势。基于此,作者综述了近年来有机余辉材料的最新进展,对已报道的有机余辉材料在生物分析和余辉成像中的医学应用进行了总结,讨论了有机余辉材料在分子构建及临床成像中的应用前景及存在的挑战。Organic afterglow material is an optical material possessing afterglow properties,and can emit light for an extended period following excitation,thereby increasing imaging duration and sensitivity.Organic afterglow materials are commonly utilized in bioanalytical imaging due to their flexible design and good biocompatibility.Owing to the light-excitation-free luminescence,the afterglow luminescence can circumvent the interference of tissue auto-fluorescence,and provide higher signal-to-background ratio and sensitivity superior to fluorescence.This review provides an overview of the recent advances in organic afterglow materials,comprehensively summarizes the reported medical applications of these materials in bioanalytical 83and afterglow imaging.Finally,the article discusses the prospects and challenges of using organic afterglow materials in molecular construction and clinical imaging.

关 键 词：有机余辉材料 余辉成像 生物传感 肿瘤诊疗 

分 类 号：O482.31[理学—固体物理]