基于数据挖掘探讨《脾胃论》风药用药规律  

Discussion on the medication law of wind drugs in Pi Wei Lun based on data mining

作　　者：潘静琳 张清[1] 朱晓霞 刘凤斌[3] 冯时茵 Pan Jinglin;Zhang Qing;Zhu Xiaoxia;Liu Fengbin;Feng Shiyin(Department of Spleen-Stomach,Guangdong Provincal Hospital of Chinese Medicine,Hainan,Hainan Traditional Chinese Medicine Hospital,Haikou 570203,China;Department of Nongyuan Community Health Service Center,the Eighth Affiliated Hospital of Sun Yat-Sen University,Shenzhen 518033,China;Department of Party Committee,Baiyun Hospital of the First Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510470,China;Department of Pharmacy,the First Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广东省中医院海南医院海南省中医院脾胃病科,海口570203 [2]中山大学附属第八医院农园社区健康服务中心,深圳518033 [3]广州中医药大学第一附属医院白云医院党委,广州510470 [4]广州中医药大学第一附属医院药学部,广州510405

出　　处：《国际中医中药杂志》2024年第6期773-777,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82060859);国家中医药管理局高水平中医药重点学科中医老年病学建设项目(琼卫中医函〔2023〕3号);海南省自然科学基金高层次人才项目(820RC775);海南省科协青年科技英才创新计划项目(QCXM202022);广东省中医药局科研项目(20221151)。

摘　　要：目的挖掘《脾胃论》风药用药规律,为临床运用风药辨治疾病提供参考。方法筛选《脾胃论》中使用风药的方剂,提取其风药及用量,采用SPSS 25.0软件对风药数据进行描述性统计,采用中医传承计算平台V3.0进行中药频次统计、中药用量统计、药物间关联规则分析等。结果纳入方剂40首(40/61,65.57%),涉及中药14味,主要有升麻、柴胡、羌活、防风、生姜等。风药古代使用剂量集中在0.68~4.00 g,最大值为8.00 g,最小值为0.09 g,现代使用剂量集中在3~10 g。常用风药剂量比例为3%~60%,其功效各有不同。关联规则算法提取风药组合为25个,升麻-柴胡支持度最高;在置信度为75%,支持度为10%、15%、20%的条件下,药物间关联规则分别为14条、7条、3条。常用风药间配比不同,其功效亦有不同。结论李东垣注重生发和升提脾阳,善用风药以升阳、补元、祛风、胜湿、散火、开郁、泻肝、通便、通窍、引经。Objective To explore the medication law of wind drugs in Pi Wei Lun;To provide reference for the clinical application of wind drugs in the diagnosis and treatment of diseases.Methods Through searching the prescriptions with wind drugs in Pi Wei Lun,wind drugs and the dosages were extracted.SPSS 25.0 software was used for descriptive statistics of wind drugs data.Traditional Chinese Medicine Inheritance Calculation Platform V3.0 was used for frequency statistics,dosage statistics and association rule analysis of Chinese materia medica.Results Totally 40 prescriptions were included(40/61,65.57%),involving 14 kinds of Chinese materia medica,mainly including Cimicifugae Rhizoma,Bupleuri Radix,Notopterygii Rhizoma et Radix,Saposhnikoviae Radix,Zingiberis Rhizoma Recens and so on.The ancient dosage of wind drugs was 0.68 g to 4.00 g,and the maximum was 8 g and the minimum was 0.09 g.However,the modern dosage was 3-10 g.The dosage ratio of commonly used of wind drugs was 3%-60%,and its efficacy varied.Through the analysis of association rules algorithm,the study gained 25 medicinal pairs,and the group Cimicifugae Rhizoma-Bupleuri Radix acquired the highest supporting degree.Under the conditions of a confidence level of 75%and support levels of 10%,15%,and 20%,there were 14,7,and 3 drug association rules,respectively.The efficacy of commonly used wind drugs varied depending on their ratio.Conclusion Li Dongyuan attached great importance to develop and ascend the yang of spleen so that he used wind drugs more often for ascending yang,supplementing the original qi,dispelling wind,dispelling dampness,dissipating heat,resolving depression,purging the liver,relaxing the bowels,unblock the orifices and directing meridians.

关 键 词：《脾胃论》 风药 用药规律 数据挖掘 

分 类 号：R288[医药卫生—中药学]