注射用复方骨肽联合常规用药治疗跟骨骨折术后患者的效果  

Effects of Compound ossotide for injection combined with conventional drug treatment in treatment of postoperative patients with calcaneal fractures

作　　者：郭彦耀 GUO Yanyao(Department of Pharmacy of the Second Hospital of Traditional Chinese Medicine,Kaifeng 475000 Henan,China)

机构地区：[1]开封市第二中医院药剂科,河南开封475000

出　　处：《中国民康医学》2024年第13期65-67,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察注射用复方骨肽联合常规用药治疗跟骨骨折术后患者的效果。方法:选取2022年6月至2023年6月该院收治的62例跟骨骨折术后患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各31例。对照组术后常规用药治疗,研究组在对照组基础上增加注射用复方骨肽治疗,比较两组小腿周径差、患肢肿胀度评分、血清骨代谢指标[骨钙素、骨碱性磷酸酶(BALP)]水平、炎性指标[血清C反应蛋白(CRP)、白细胞计数(WBC)]水平、疼痛视觉模拟评分法(VAS)评分和并发症发生率。结果:术后2周,血清骨钙素、BALP等血清骨代谢指标水平高于术后1 d,且研究组高于对照组,两组小腿周径差、患肢肿胀度评分、CRP水平、WBC水平、VAS评分低于术后1 d,且研究组低于对照组,差异均有统计学意义(P<0.05);住院期间,两组皮缘坏死、血肿、切口感染等并发症发生率比较,差异均无统计学意义(P>0.05)。结论:注射用复方骨肽联合常规用药治疗跟骨骨折术后患者可提高其骨代谢指标水平,降低小腿周径差、患肢肿胀度评分、VAS评分以及炎性指标水平,效果优于单纯常规用药治疗。Objective:To observe effects of Compound ossotide for injection combined with conventional drug treatment in treatment of postoperative patients with calcaneal fractures.Methods:62 patients with calcaneal fractures treated in this hospital from June 2022 to June 2023were selected for the prospective study.According to the random number table method,they were divided into study group and control group,31 cases in each group.The control group was treated with conventional drug treatment after the surgery,while the study group was treated with compound ossotide on the basis of that of the control group.The calf circumference,the swelling degree score of affected limb,the serum bone metabolism index [osteocalcin,bone alkaline phosphatase(BALP)] levels,the inflammatory index [serum C-reactive protein(CRP),white blood cell count(WBC)]levels,the pain visual analogue scale(VAS) score,and the incidence of complications were compared between the two groups.Results:2 weeks after the surgery,the levels of serum bone metabolism indexes such as serum osteocalcin and BALP were higher than those on the first day after the surgery,and those in the study group were higher than those in the control group;the calf circumference,the swelling degree scores of affected limb,the CRP levels,the WBC levels and the VAS scores of the two groups were lower than those on the first day after the surgery,and the those in study group were lower than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Compound ossotide for injection combined with conventional drugs in the treatment of the postoperative patients with calcaneal fractures can improve the levels of bone metabolism indexes,and reduce the difference of calf circumference,the swelling degree scores of affected limb,the VAS scores and the inflammatory index levels.Moreover,it is superior to single conventional drug treatment.

关 键 词：注射用复方骨肽 跟骨骨折术后 骨代谢 小腿周径 患肢肿胀度 并发症 

分 类 号：R9[医药卫生—药学]