司库奇尤单抗联合卡泊三醇乳膏治疗中重度银屑病患者的效果  

Effects of Secukinumab combined with Calcipotriol cream in treatment of patients with moderate to severe psoriasis

作　　者：骆焕 党梦娜 LUO Huan;DANG Mengna(Department of Dermatology Zhumadian First People’s Hospital,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店市第一人民医院皮肤科,河南驻马店463000

出　　处：《中国民康医学》2024年第13期78-80,84,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察司库奇尤单抗联合卡泊三醇乳膏治疗中重度银屑病患者的效果。方法:选取2021年1月至2023年6月该院收治的68例中重度银屑病患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各34例。对照组给予卡泊三醇乳膏治疗,观察组在对照组基础上联合司库奇尤单抗治疗。比较两组临床疗效、临床症状消失时间、皮肤屏障功能指标[皮脂含量、角质层含水量、经表皮水分丢失量(TEWL)]水平、血清学指标[白细胞介素-2(IL-2)、γ干扰素(IFN-γ)]水平及不良反应发生率。结果:观察组治疗总有效率为97.06%(33/34),高于对照组的76.47%(26/34),差异有统计学意义(P<0.05);观察组皮肤瘙痒、红斑、鳞屑、脱屑等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);两组角质层含水量、皮脂含量均高于治疗前,且观察组高于对照组,两组TEWL均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IL-2、IFN-γ水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计意义(P>0.05)。结论:司库奇尤单抗联合卡泊三醇乳膏治疗中重度银屑病患者,可提高临床疗效,缩短临床症状消失时间,改善皮肤屏障功能指标和血清学指标水平,效果优于单纯卡泊三醇乳膏治疗。Objective:To observe effects of Secukinumab combined with Calcipotriol cream in treatment of patients with moderate to severe psoriasis.Methods:A prospective study was conducted on 68 patients with moderate to severe psoriasis admitted to the hospital from January 2021 to June 2023.According to the random number table method,they were divided into control group and observation group,34 cases in each group.The control group was treated with Calcipotriol cream,while the observation group was treated with Secukinumab on the basis of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the skin barrier function indicators [sebum content,stratum corneum water content,transepidermal water loss(TEWL)] levels,the serological indicators [interleukin-2(IL-2),γ-interferon(IFN-γ)] levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.06%(33/34),which was higher than that of the control group 76.47%(26/34),and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as skin itching,erythema,scales and desquamation in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The water content and sebum content of stratum corneum in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the TEWL levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of IL-2 and IFN-γ in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0

关 键 词：银屑病 司库奇尤单抗 卡泊三醇乳膏 临床症状 皮肤屏障 不良反应 

分 类 号：R986[医药卫生—药品]