血清HIF-1α、SP-D、Copeptin水平联合检测预测慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者预后的价值  

Value of combined detection of serum HIF-1α,SP-D and Copeptin levels in prediction of prognosis of patients with chronic obstructive pulmonary disease complicated with type II respiratory failure

作　　者：刘华伟 LIU Huawei(Respiratory Department of Zhoukou Infectious Disease Hospital,Zhoukou 466000 Henan,China)

机构地区：[1]周口市传染病医院呼吸科,河南周口466000

出　　处：《中国民康医学》2024年第13期132-135,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清缺氧诱导因子-1α(HIF-1α)、肺表面活性物质蛋白D(SP-D)、和肽素(Copeptin)水平联合检测预测慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者预后的价值。方法:选取2022年该院收治的66例COPD合并Ⅱ型呼吸衰竭患者进行前瞻性研究,设为研究组,根据治疗14 d后预后情况将其分为预后不良(n=21)和预后良好(n=45);另选取同期66名健康体检者,设为对照组。比较两组入院时血清HIF-1α、SP-D、Copeptin水平,并采用Spearman相关性分析血清HIF-1α、SP-D、Copeptin水平与预后的相关性,绘制受试者工作特征(ROC)曲线分析治疗7 d后血清HIF-1α、SP-D、Copeptin水平单项及联合检测预测COPD合并Ⅱ型呼吸衰竭患者预后的价值。结果:入院时,研究组HIF-1α、SP-D、Copeptin水平均高于对照组,差异有统计学意义(P<0.05);治疗7 d后,预后良好患者血清Copeptin、SP-D、HIF-1α水平均低于预后不良患者,差异有统计学意义(P<0.05);血清HIF-1α、SP-D、Copeptin水平均与COPD合并Ⅱ型呼吸衰竭患者预后呈正相关(r>0,P<0.05);ROC曲线分析结果显示,血清HIF-1α、SP-D、Copeptin水平单项及联合检测预测COPD合并Ⅱ型呼吸衰竭患者预后的曲线下面积分别为0.828、0759、0.813、0.905,其中联合检测预测价值最高。结论:血清HIF-1α、SP-D、Copeptin水平联合检测预测COPD合并Ⅱ型呼吸衰竭患者预后的价值高于三者单项检测。Objective:To analyze value of combined detection of serum hypoxia-inducible factor-1α(HIF-1α),surfactant protein D(SP-D) and Copeptin levels in prediction of prognosis of patients with chronic obstructive pulmonary disease(COPD) complicated with type II respiratory failure.Methods:66 patients with chronic obstructive pulmonary disease complicated with type II respiratory failure admitted to this hospital from 2022 were selected for the prospective study and they were set as the study group.According to the prognosis after 14 days of treatment,they were divided into the patients with poor prognosis(n=21) and the patients with good prognosis(n=45).Another 66 healthy subjects were selected as the control group.The levels of serum HIF-1α,SP-D and Copeptin were compared between the two groups at admission.Spearman correlation analysis was used to analyze the correlations among the serum HIF-1α,SP-D,Copeptin levels and prognosis.The receiver operating characteristic(ROC)curve was drawn to analyze the value of single and combined detection of serum HIF-1α,SP-D and Copeptin levels in the prediction of the prognosis of the patients with COPD complicated with type II respiratory failure after 7 days of treatment.Results:On admission,the levels of HIF-1α,SP-D and Copeptin in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 7 days of treatment,the levels of serum Copeptin,SP-D and HIF-1α in the patients with good prognosis were lower than those in the patients with poor prognosis,and the differences were statistically significant(P<0.05).The levels of serum HIF-1α,SP-D and Copeptin were positively correlated with the prognosis of the COPD patients with type II respiratory failure(r>0,P<0.05).ROC curve showed that the AUCs of single and combined detection of serum HIF-1α,SP-D and Copeptin levels in the prediction of the prognosis of the COPD patients with type II respiratory failure were 0.828,0759,0.813 and 0.905,separately,and the combined

关 键 词：慢性阻塞性肺疾病 Ⅱ型呼吸衰竭 缺氧诱导因子1Α 肺表面活性物质蛋白D 和肽素 

分 类 号：R541.6[医药卫生—心血管疾病]